Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial

BACKGROUND: We have determined that the impaired accommodation of the lower esophageal sphincter (LES) underlies the pathogenesis of esophagogastric junction outflow obstruction (EGJOO). We have also found that acotiamide may treat EGJOO by improving impaired LES accommodation. The effects of acotia...

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Detalles Bibliográficos
Autores principales: Esaki, Mitsuru, Ihara, Eikichi, Manabe, Noriaki, Kawami, Noriyuki, Iwakiri, Katsuhiko, Akiyama, Junichi, Kuribayashi, Shiko, Uraoka, Toshio, Ogino, Haruei, Chinen, Takatoshi, Misumi, Akiko, Watanabe, Hiroko, Suzuki, Maya, Kishimoto, Junji, Ogawa, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354885/
https://www.ncbi.nlm.nih.gov/pubmed/37464279
http://dx.doi.org/10.1186/s13063-023-07468-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354885/
https://www.ncbi.nlm.nih.gov/pubmed/37464279
http://dx.doi.org/10.1186/s13063-023-07468-w

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