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Invasive Group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center
BACKGROUND: In pediatric age, Group A Streptococcus (GAS) is responsible for a wide spectrum of clinical manifestations, from mild localized infections to life-threatening invasive diseases. In December 2022, the World Health Organization reported an increased incidence of scarlet fever and invasive...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354902/ https://www.ncbi.nlm.nih.gov/pubmed/37468965 http://dx.doi.org/10.1186/s13052-023-01494-9 |
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author | Garancini, Nicolò Ricci, Giulia Ghezzi, Michele Tommasi, Paola Zunica, Fiammetta Mandelli, Anna Zoia, Elena D’Auria, Enza Zuccotti, Gian Vincenzo |
author_facet | Garancini, Nicolò Ricci, Giulia Ghezzi, Michele Tommasi, Paola Zunica, Fiammetta Mandelli, Anna Zoia, Elena D’Auria, Enza Zuccotti, Gian Vincenzo |
author_sort | Garancini, Nicolò |
collection | PubMed |
description | BACKGROUND: In pediatric age, Group A Streptococcus (GAS) is responsible for a wide spectrum of clinical manifestations, from mild localized infections to life-threatening invasive diseases. In December 2022, the World Health Organization reported an increased incidence of scarlet fever and invasive GAS infections (iGAS) cases in Europe and the United States. In line with these observations, surveillance has been strengthened in our Region, allowing the identification of certified or highly suspected forms of iGAS. CASE PRESENTATION: We report here 4 emblematic cases of iGAS admitted to our Intensive Care Unit (ICU) in the short time span from mid-February to mid-March 2023. Particularly, we describe a case of pleuropneumonia (4 year old boy) and a case of respiratory failure (2 year old boy), who necessitated Non-Invasive Ventilation support, a case of Streptococcal Toxic Shock Syndrome (6 year old girl), presenting with multi-organ failure, who needed Invasive Ventilation, and a case of meningitis (5 year old girl). All these patients needed intensive care support. CONCLUSIONS: Accurate differential diagnosis and early treatment both could help to reduce the transmission of GAS and consequently the risk of severe iGAS. These cases confirmed the need for close monitoring and appropriate notification, in order to verify their actual increased incidence. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13052-023-01494-9. |
format | Online Article Text |
id | pubmed-10354902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-103549022023-07-20 Invasive Group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center Garancini, Nicolò Ricci, Giulia Ghezzi, Michele Tommasi, Paola Zunica, Fiammetta Mandelli, Anna Zoia, Elena D’Auria, Enza Zuccotti, Gian Vincenzo Ital J Pediatr Case Report BACKGROUND: In pediatric age, Group A Streptococcus (GAS) is responsible for a wide spectrum of clinical manifestations, from mild localized infections to life-threatening invasive diseases. In December 2022, the World Health Organization reported an increased incidence of scarlet fever and invasive GAS infections (iGAS) cases in Europe and the United States. In line with these observations, surveillance has been strengthened in our Region, allowing the identification of certified or highly suspected forms of iGAS. CASE PRESENTATION: We report here 4 emblematic cases of iGAS admitted to our Intensive Care Unit (ICU) in the short time span from mid-February to mid-March 2023. Particularly, we describe a case of pleuropneumonia (4 year old boy) and a case of respiratory failure (2 year old boy), who necessitated Non-Invasive Ventilation support, a case of Streptococcal Toxic Shock Syndrome (6 year old girl), presenting with multi-organ failure, who needed Invasive Ventilation, and a case of meningitis (5 year old girl). All these patients needed intensive care support. CONCLUSIONS: Accurate differential diagnosis and early treatment both could help to reduce the transmission of GAS and consequently the risk of severe iGAS. These cases confirmed the need for close monitoring and appropriate notification, in order to verify their actual increased incidence. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13052-023-01494-9. BioMed Central 2023-07-19 /pmc/articles/PMC10354902/ /pubmed/37468965 http://dx.doi.org/10.1186/s13052-023-01494-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Garancini, Nicolò Ricci, Giulia Ghezzi, Michele Tommasi, Paola Zunica, Fiammetta Mandelli, Anna Zoia, Elena D’Auria, Enza Zuccotti, Gian Vincenzo Invasive Group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center |
title | Invasive Group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center |
title_full | Invasive Group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center |
title_fullStr | Invasive Group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center |
title_full_unstemmed | Invasive Group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center |
title_short | Invasive Group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center |
title_sort | invasive group a streptococcal infections: are we facing a new outbreak? a case series with the experience of a single tertiary center |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354902/ https://www.ncbi.nlm.nih.gov/pubmed/37468965 http://dx.doi.org/10.1186/s13052-023-01494-9 |
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