Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy

BACKGROUND: Emerging evidence from mouse models is beginning to elucidate the brain’s immune response to tau pathology, but little is known about the nature of this response in humans. In addition, it remains unclear to what extent tau pathology and the local inflammatory response within the brain i...

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Detalles Bibliográficos
Autores principales: Sirkis, Daniel W., Warly Solsberg, Caroline, Johnson, Taylor P., Bonham, Luke W., Sturm, Virginia E., Lee, Suzee E., Rankin, Katherine P., Rosen, Howard J., Boxer, Adam L., Seeley, William W., Miller, Bruce L., Geier, Ethan G., Yokoyama, Jennifer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354988/
https://www.ncbi.nlm.nih.gov/pubmed/37464408
http://dx.doi.org/10.1186/s13073-023-01205-3

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