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DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming

BACKGROUND: DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been reported that DNMT3A mutation plays a key role in leukemogenesis through hypomethylation of some target genes associated with cell growth an...

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Detalles Bibliográficos
Autores principales:	Yang, Xuejiao, Wang, Xiao, Yang, Ying, Li, Zhiyang, Chen, Yunshuo, Shang, Siqi, Wang, Yueying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355022/ https://www.ncbi.nlm.nih.gov/pubmed/37464424 http://dx.doi.org/10.1186/s12967-023-04323-z

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