Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review

Langerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by infiltration of histiocytes and dendritic cells into body organs. While treatment is better established in pediatrics, there is still no consensus on therapy in the adult population. Imatinib has shown promising result...

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Autores principales: Abdulgayoom, Mohammed, Mudawi, Deena, Lengyel, Zsolt, Abo Samra, Hayan, Alshurafa, Awni, Yassin, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355039/
https://www.ncbi.nlm.nih.gov/pubmed/37476563
http://dx.doi.org/10.1159/000531230
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author Abdulgayoom, Mohammed
Mudawi, Deena
Lengyel, Zsolt
Abo Samra, Hayan
Alshurafa, Awni
Yassin, Mohamed A.
author_facet Abdulgayoom, Mohammed
Mudawi, Deena
Lengyel, Zsolt
Abo Samra, Hayan
Alshurafa, Awni
Yassin, Mohamed A.
author_sort Abdulgayoom, Mohammed
collection PubMed
description Langerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by infiltration of histiocytes and dendritic cells into body organs. While treatment is better established in pediatrics, there is still no consensus on therapy in the adult population. Imatinib has shown promising results in some case reports and a small clinical trial. We present here a fifty-nine-year-old patient with LCH in the lung, liver, and bone who responded well to an imatinib dose of 100 mg daily. Her symptoms improved within 3 months of treatment, and subsequent positron emission tomography-computed tomography (PET/CT) showed resolution of 18F-fluorodeoxyglucose (FDG)-avid lesions.
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spelling pubmed-103550392023-07-20 Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review Abdulgayoom, Mohammed Mudawi, Deena Lengyel, Zsolt Abo Samra, Hayan Alshurafa, Awni Yassin, Mohamed A. Case Rep Oncol Case Report Langerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by infiltration of histiocytes and dendritic cells into body organs. While treatment is better established in pediatrics, there is still no consensus on therapy in the adult population. Imatinib has shown promising results in some case reports and a small clinical trial. We present here a fifty-nine-year-old patient with LCH in the lung, liver, and bone who responded well to an imatinib dose of 100 mg daily. Her symptoms improved within 3 months of treatment, and subsequent positron emission tomography-computed tomography (PET/CT) showed resolution of 18F-fluorodeoxyglucose (FDG)-avid lesions. S. Karger AG 2023-07-12 /pmc/articles/PMC10355039/ /pubmed/37476563 http://dx.doi.org/10.1159/000531230 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Abdulgayoom, Mohammed
Mudawi, Deena
Lengyel, Zsolt
Abo Samra, Hayan
Alshurafa, Awni
Yassin, Mohamed A.
Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review
title Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review
title_full Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review
title_fullStr Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review
title_full_unstemmed Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review
title_short Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review
title_sort langerhans cell histiocytosis with good response to low-dose imatinib: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355039/
https://www.ncbi.nlm.nih.gov/pubmed/37476563
http://dx.doi.org/10.1159/000531230
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