A focus on 1-azahomocubane: the new kid on the block

Strained hydrocarbons have recently regained interest as potential drug candidates. However, the study of their heteroatom analogs has remained limited, despite differing by only a single atom. The first synthesis of 1-azahomocubane by Williams, Eaton and co-workers (T. Fahrenhorst-Jones et al., Che...

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Detalles Bibliográficos
Autores principales: Elgindy, Cecile, Levin, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355093/
https://www.ncbi.nlm.nih.gov/pubmed/37476719
http://dx.doi.org/10.1039/d3sc90114a
Descripción
Sumario:Strained hydrocarbons have recently regained interest as potential drug candidates. However, the study of their heteroatom analogs has remained limited, despite differing by only a single atom. The first synthesis of 1-azahomocubane by Williams, Eaton and co-workers (T. Fahrenhorst-Jones et al., Chem. Sci., 2023, 14, 2821–2825, https://doi.org/10.1039/D3SC00001J) is discussed within the context of nitrogen scanning of strained hydrocarbons.

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