A focus on 1-azahomocubane: the new kid on the block

Strained hydrocarbons have recently regained interest as potential drug candidates. However, the study of their heteroatom analogs has remained limited, despite differing by only a single atom. The first synthesis of 1-azahomocubane by Williams, Eaton and co-workers (T. Fahrenhorst-Jones et al., Che...

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Detalles Bibliográficos
Autores principales: Elgindy, Cecile, Levin, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355093/
https://www.ncbi.nlm.nih.gov/pubmed/37476719
http://dx.doi.org/10.1039/d3sc90114a
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author Elgindy, Cecile
Levin, Mark D.
author_facet Elgindy, Cecile
Levin, Mark D.
author_sort Elgindy, Cecile
collection PubMed
description Strained hydrocarbons have recently regained interest as potential drug candidates. However, the study of their heteroatom analogs has remained limited, despite differing by only a single atom. The first synthesis of 1-azahomocubane by Williams, Eaton and co-workers (T. Fahrenhorst-Jones et al., Chem. Sci., 2023, 14, 2821–2825, https://doi.org/10.1039/D3SC00001J) is discussed within the context of nitrogen scanning of strained hydrocarbons.
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spelling pubmed-103550932023-07-20 A focus on 1-azahomocubane: the new kid on the block Elgindy, Cecile Levin, Mark D. Chem Sci Chemistry Strained hydrocarbons have recently regained interest as potential drug candidates. However, the study of their heteroatom analogs has remained limited, despite differing by only a single atom. The first synthesis of 1-azahomocubane by Williams, Eaton and co-workers (T. Fahrenhorst-Jones et al., Chem. Sci., 2023, 14, 2821–2825, https://doi.org/10.1039/D3SC00001J) is discussed within the context of nitrogen scanning of strained hydrocarbons. The Royal Society of Chemistry 2023-07-07 /pmc/articles/PMC10355093/ /pubmed/37476719 http://dx.doi.org/10.1039/d3sc90114a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Elgindy, Cecile
Levin, Mark D.
A focus on 1-azahomocubane: the new kid on the block
title A focus on 1-azahomocubane: the new kid on the block
title_full A focus on 1-azahomocubane: the new kid on the block
title_fullStr A focus on 1-azahomocubane: the new kid on the block
title_full_unstemmed A focus on 1-azahomocubane: the new kid on the block
title_short A focus on 1-azahomocubane: the new kid on the block
title_sort focus on 1-azahomocubane: the new kid on the block
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355093/
https://www.ncbi.nlm.nih.gov/pubmed/37476719
http://dx.doi.org/10.1039/d3sc90114a
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