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Development of 8–17 XNAzymes that are functional in cells

DNA enzymes (DNAzymes), which cleave target RNA with high specificity, have been widely investigated as potential oligonucleotide-based therapeutics. Recently, xeno-nucleic acid (XNA)-modified DNAzymes (XNAzymes), exhibiting cleavage activity in cultured cells, have been developed. However, a versat...

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Detalles Bibliográficos
Autores principales:	Chiba, Kosuke, Yamaguchi, Takao, Obika, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355097/ https://www.ncbi.nlm.nih.gov/pubmed/37476720 http://dx.doi.org/10.1039/d3sc01928d

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