Site-selective carbonylation of arenes via C(sp(2))–H thianthrenation: direct access to 1,2-diarylethanones

Herein, a new reaction for the site-selective carbonylation of arenes via C(sp(2))–H thianthrenation under mild conditions has been developed. With low loadings of palladium catalysts, various desired 1,2-diarylethanones are produced in good yields. This strategy also enables the late-stage modifica...

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Detalles Bibliográficos
Autores principales: Zhang, Jiajun, Wang, Le-Cheng, Bao, Zhi-Peng, Wu, Xiao-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355103/
https://www.ncbi.nlm.nih.gov/pubmed/37476721
http://dx.doi.org/10.1039/d3sc02402d
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author Zhang, Jiajun
Wang, Le-Cheng
Bao, Zhi-Peng
Wu, Xiao-Feng
author_facet Zhang, Jiajun
Wang, Le-Cheng
Bao, Zhi-Peng
Wu, Xiao-Feng
author_sort Zhang, Jiajun
collection PubMed
description Herein, a new reaction for the site-selective carbonylation of arenes via C(sp(2))–H thianthrenation under mild conditions has been developed. With low loadings of palladium catalysts, various desired 1,2-diarylethanones are produced in good yields. This strategy also enables the late-stage modification of complex molecules, which was previously challenging with similar carbonylative Negishi-type reactions.
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spelling pubmed-103551032023-07-20 Site-selective carbonylation of arenes via C(sp(2))–H thianthrenation: direct access to 1,2-diarylethanones Zhang, Jiajun Wang, Le-Cheng Bao, Zhi-Peng Wu, Xiao-Feng Chem Sci Chemistry Herein, a new reaction for the site-selective carbonylation of arenes via C(sp(2))–H thianthrenation under mild conditions has been developed. With low loadings of palladium catalysts, various desired 1,2-diarylethanones are produced in good yields. This strategy also enables the late-stage modification of complex molecules, which was previously challenging with similar carbonylative Negishi-type reactions. The Royal Society of Chemistry 2023-06-16 /pmc/articles/PMC10355103/ /pubmed/37476721 http://dx.doi.org/10.1039/d3sc02402d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhang, Jiajun
Wang, Le-Cheng
Bao, Zhi-Peng
Wu, Xiao-Feng
Site-selective carbonylation of arenes via C(sp(2))–H thianthrenation: direct access to 1,2-diarylethanones
title Site-selective carbonylation of arenes via C(sp(2))–H thianthrenation: direct access to 1,2-diarylethanones
title_full Site-selective carbonylation of arenes via C(sp(2))–H thianthrenation: direct access to 1,2-diarylethanones
title_fullStr Site-selective carbonylation of arenes via C(sp(2))–H thianthrenation: direct access to 1,2-diarylethanones
title_full_unstemmed Site-selective carbonylation of arenes via C(sp(2))–H thianthrenation: direct access to 1,2-diarylethanones
title_short Site-selective carbonylation of arenes via C(sp(2))–H thianthrenation: direct access to 1,2-diarylethanones
title_sort site-selective carbonylation of arenes via c(sp(2))–h thianthrenation: direct access to 1,2-diarylethanones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355103/
https://www.ncbi.nlm.nih.gov/pubmed/37476721
http://dx.doi.org/10.1039/d3sc02402d
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