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IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation

Germinal center (GC) dysregulation has been widely reported in the context of autoimmunity. Here, we show that interleukin 21 (IL-21), the archetypal follicular helper T cell (Tfh) cytokine, shapes the scale and polarization of spontaneous chronic autoimmune as well as transient immunization-induced...

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Detalles Bibliográficos
Autores principales:	Petersone, Lina, Wang, Chun Jing, Edner, Natalie M., Fabri, Astrid, Nikou, Spyridoula-Angeliki, Hinze, Claudia, Ross, Ellen M., Ntavli, Elisavet, Elfaki, Yassin, Heuts, Frank, Ovcinnikovs, Vitalijs, Rueda Gonzalez, Andrea, Houghton, Luke P., Li, Hannah M., Zhang, Yang, Toellner, Kai-Michael, Walker, Lucy S.K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355162/ https://www.ncbi.nlm.nih.gov/pubmed/37466652 http://dx.doi.org/10.1084/jem.20221653

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