Metal-free C-3 selective C(sp(2))–C(sp(3)) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling

A general and straightforward method for the regioselective construction of C-3 heteroaryl-containing imidazo[1,2-a]pyridines via cross-dehydrogenative coupling under transition-metal-free conditions has been reported, utilizing N,N-dimethylaniline as the methylenation source and furnishing the C(sp...

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Autores principales: Wang, Kai, Du, Xiaoxue, Zhang, Pengfei, Wei, Zhenjiang, Cao, Xian-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355276/
https://www.ncbi.nlm.nih.gov/pubmed/37476046
http://dx.doi.org/10.1039/d3ra03852a
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author Wang, Kai
Du, Xiaoxue
Zhang, Pengfei
Wei, Zhenjiang
Cao, Xian-Ting
author_facet Wang, Kai
Du, Xiaoxue
Zhang, Pengfei
Wei, Zhenjiang
Cao, Xian-Ting
author_sort Wang, Kai
collection PubMed
description A general and straightforward method for the regioselective construction of C-3 heteroaryl-containing imidazo[1,2-a]pyridines via cross-dehydrogenative coupling under transition-metal-free conditions has been reported, utilizing N,N-dimethylaniline as the methylenation source and furnishing the C(sp(2))–C(sp(3)) functionalized products in good to excellent yields. Mechanism studies indicate that a radical pathway is responsible for this transformation.
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spelling pubmed-103552762023-07-20 Metal-free C-3 selective C(sp(2))–C(sp(3)) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling Wang, Kai Du, Xiaoxue Zhang, Pengfei Wei, Zhenjiang Cao, Xian-Ting RSC Adv Chemistry A general and straightforward method for the regioselective construction of C-3 heteroaryl-containing imidazo[1,2-a]pyridines via cross-dehydrogenative coupling under transition-metal-free conditions has been reported, utilizing N,N-dimethylaniline as the methylenation source and furnishing the C(sp(2))–C(sp(3)) functionalized products in good to excellent yields. Mechanism studies indicate that a radical pathway is responsible for this transformation. The Royal Society of Chemistry 2023-07-19 /pmc/articles/PMC10355276/ /pubmed/37476046 http://dx.doi.org/10.1039/d3ra03852a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wang, Kai
Du, Xiaoxue
Zhang, Pengfei
Wei, Zhenjiang
Cao, Xian-Ting
Metal-free C-3 selective C(sp(2))–C(sp(3)) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling
title Metal-free C-3 selective C(sp(2))–C(sp(3)) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling
title_full Metal-free C-3 selective C(sp(2))–C(sp(3)) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling
title_fullStr Metal-free C-3 selective C(sp(2))–C(sp(3)) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling
title_full_unstemmed Metal-free C-3 selective C(sp(2))–C(sp(3)) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling
title_short Metal-free C-3 selective C(sp(2))–C(sp(3)) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling
title_sort metal-free c-3 selective c(sp(2))–c(sp(3)) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355276/
https://www.ncbi.nlm.nih.gov/pubmed/37476046
http://dx.doi.org/10.1039/d3ra03852a
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