The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review

The complicated connections and cross talk between the skeletal system and the immune system are attracting more attention, which is developing into the field of Osteoimmunology. In this field, cytokines that are among osteoblasts and osteoclasts play a critical role in bone remodeling, which is a p...

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Autores principales: Xu, Jie, Yu, Linxin, Liu, Feng, Wan, Longbiao, Deng, Zhenhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355373/
https://www.ncbi.nlm.nih.gov/pubmed/37475866
http://dx.doi.org/10.3389/fimmu.2023.1222129
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author Xu, Jie
Yu, Linxin
Liu, Feng
Wan, Longbiao
Deng, Zhenhua
author_facet Xu, Jie
Yu, Linxin
Liu, Feng
Wan, Longbiao
Deng, Zhenhua
author_sort Xu, Jie
collection PubMed
description The complicated connections and cross talk between the skeletal system and the immune system are attracting more attention, which is developing into the field of Osteoimmunology. In this field, cytokines that are among osteoblasts and osteoclasts play a critical role in bone remodeling, which is a pathological process in the pathogenesis and development of osteoporosis. Those cytokines include the tumor necrosis factor (TNF) family, the interleukin (IL) family, interferon (IFN), chemokines, and so on, most of which influence the bone microenvironment, osteoblasts, and osteoclasts. This review summarizes the effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis, aiming to providing the latest reference to the role of immunology in osteoporosis.
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spelling pubmed-103553732023-07-20 The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review Xu, Jie Yu, Linxin Liu, Feng Wan, Longbiao Deng, Zhenhua Front Immunol Immunology The complicated connections and cross talk between the skeletal system and the immune system are attracting more attention, which is developing into the field of Osteoimmunology. In this field, cytokines that are among osteoblasts and osteoclasts play a critical role in bone remodeling, which is a pathological process in the pathogenesis and development of osteoporosis. Those cytokines include the tumor necrosis factor (TNF) family, the interleukin (IL) family, interferon (IFN), chemokines, and so on, most of which influence the bone microenvironment, osteoblasts, and osteoclasts. This review summarizes the effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis, aiming to providing the latest reference to the role of immunology in osteoporosis. Frontiers Media S.A. 2023-07-05 /pmc/articles/PMC10355373/ /pubmed/37475866 http://dx.doi.org/10.3389/fimmu.2023.1222129 Text en Copyright © 2023 Xu, Yu, Liu, Wan and Deng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xu, Jie
Yu, Linxin
Liu, Feng
Wan, Longbiao
Deng, Zhenhua
The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
title The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
title_full The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
title_fullStr The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
title_full_unstemmed The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
title_short The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
title_sort effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355373/
https://www.ncbi.nlm.nih.gov/pubmed/37475866
http://dx.doi.org/10.3389/fimmu.2023.1222129
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