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Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study

BACKGROUND: Although observational studies have shown that physical activity is a protective factor for acute pancreatitis, the causal associations between PA/ sedentary behavior and acute pancreatitis (AP) and chronic pancreatitis (CP) remain unclear. METHODS: We used Mendelian randomization as a s...

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Autores principales: Ling, Ruiqi, Liang, Juan, Mo, Shaojian, Qi, Jiabao, Fu, Xifeng, Tian, Yanzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355380/
https://www.ncbi.nlm.nih.gov/pubmed/37467250
http://dx.doi.org/10.1371/journal.pone.0287810
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author Ling, Ruiqi
Liang, Juan
Mo, Shaojian
Qi, Jiabao
Fu, Xifeng
Tian, Yanzhang
author_facet Ling, Ruiqi
Liang, Juan
Mo, Shaojian
Qi, Jiabao
Fu, Xifeng
Tian, Yanzhang
author_sort Ling, Ruiqi
collection PubMed
description BACKGROUND: Although observational studies have shown that physical activity is a protective factor for acute pancreatitis, the causal associations between PA/ sedentary behavior and acute pancreatitis (AP) and chronic pancreatitis (CP) remain unclear. METHODS: We used Mendelian randomization as a strategy to assess the causalities between exposures and outcomes by simulating randomized experiments with genetic variation. The collected genetic variants data of physical activity were from UK Biobank, the data on sedentary behavior were also from UK Biobank, and both of them could be found in the GWAS catalog, and the data on AP and CP were from FinnGen. There were three physical activity related activity patterns (moderate to vigorous physical activity [MVPA], accelerometer-based physical activity with average acceleration, [AccAve] and accelerometer-based physical activity with accelerations >425 milli-gravities, [Acc425]) and three sedentary behavior-related lifestyle patterns (Leisure screen time [LST], Sedentary commuting, Sedentary behavior at work). We used inverse variance weighted (IVW), weighted median and MR-Egger for the analysis of Mendelian randomization, followed by sensitivity tests with the Cochran Q test, MR-Egger intercepts analysis and MR-PRESSO. RESULTS: A causal relationship was found between LST and acute pancreatitis based on IVW analysis (odds ratios [OR] = 1.38, corresponding 95% confidence intervals [CI] = 1.16–1.64, p = 0.0002) and there were no causal relationships between physical activity/sedentary behavior and chronic pancreatitis. Sensitivity analysis showed no pleiotropy and heterogeneity of the results. CONCLUSIONS: Results show that reducing LST contributes to the prevention of acute pancreatitis, thereby reducing the health burden associated with it.
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spelling pubmed-103553802023-07-20 Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study Ling, Ruiqi Liang, Juan Mo, Shaojian Qi, Jiabao Fu, Xifeng Tian, Yanzhang PLoS One Research Article BACKGROUND: Although observational studies have shown that physical activity is a protective factor for acute pancreatitis, the causal associations between PA/ sedentary behavior and acute pancreatitis (AP) and chronic pancreatitis (CP) remain unclear. METHODS: We used Mendelian randomization as a strategy to assess the causalities between exposures and outcomes by simulating randomized experiments with genetic variation. The collected genetic variants data of physical activity were from UK Biobank, the data on sedentary behavior were also from UK Biobank, and both of them could be found in the GWAS catalog, and the data on AP and CP were from FinnGen. There were three physical activity related activity patterns (moderate to vigorous physical activity [MVPA], accelerometer-based physical activity with average acceleration, [AccAve] and accelerometer-based physical activity with accelerations >425 milli-gravities, [Acc425]) and three sedentary behavior-related lifestyle patterns (Leisure screen time [LST], Sedentary commuting, Sedentary behavior at work). We used inverse variance weighted (IVW), weighted median and MR-Egger for the analysis of Mendelian randomization, followed by sensitivity tests with the Cochran Q test, MR-Egger intercepts analysis and MR-PRESSO. RESULTS: A causal relationship was found between LST and acute pancreatitis based on IVW analysis (odds ratios [OR] = 1.38, corresponding 95% confidence intervals [CI] = 1.16–1.64, p = 0.0002) and there were no causal relationships between physical activity/sedentary behavior and chronic pancreatitis. Sensitivity analysis showed no pleiotropy and heterogeneity of the results. CONCLUSIONS: Results show that reducing LST contributes to the prevention of acute pancreatitis, thereby reducing the health burden associated with it. Public Library of Science 2023-07-19 /pmc/articles/PMC10355380/ /pubmed/37467250 http://dx.doi.org/10.1371/journal.pone.0287810 Text en © 2023 Ling et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ling, Ruiqi
Liang, Juan
Mo, Shaojian
Qi, Jiabao
Fu, Xifeng
Tian, Yanzhang
Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study
title Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study
title_full Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study
title_fullStr Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study
title_full_unstemmed Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study
title_short Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study
title_sort physical activity, sedentary behavior and pancreatitis risk: mendelian randomization study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355380/
https://www.ncbi.nlm.nih.gov/pubmed/37467250
http://dx.doi.org/10.1371/journal.pone.0287810
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