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Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study
BACKGROUND: Although observational studies have shown that physical activity is a protective factor for acute pancreatitis, the causal associations between PA/ sedentary behavior and acute pancreatitis (AP) and chronic pancreatitis (CP) remain unclear. METHODS: We used Mendelian randomization as a s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355380/ https://www.ncbi.nlm.nih.gov/pubmed/37467250 http://dx.doi.org/10.1371/journal.pone.0287810 |
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author | Ling, Ruiqi Liang, Juan Mo, Shaojian Qi, Jiabao Fu, Xifeng Tian, Yanzhang |
author_facet | Ling, Ruiqi Liang, Juan Mo, Shaojian Qi, Jiabao Fu, Xifeng Tian, Yanzhang |
author_sort | Ling, Ruiqi |
collection | PubMed |
description | BACKGROUND: Although observational studies have shown that physical activity is a protective factor for acute pancreatitis, the causal associations between PA/ sedentary behavior and acute pancreatitis (AP) and chronic pancreatitis (CP) remain unclear. METHODS: We used Mendelian randomization as a strategy to assess the causalities between exposures and outcomes by simulating randomized experiments with genetic variation. The collected genetic variants data of physical activity were from UK Biobank, the data on sedentary behavior were also from UK Biobank, and both of them could be found in the GWAS catalog, and the data on AP and CP were from FinnGen. There were three physical activity related activity patterns (moderate to vigorous physical activity [MVPA], accelerometer-based physical activity with average acceleration, [AccAve] and accelerometer-based physical activity with accelerations >425 milli-gravities, [Acc425]) and three sedentary behavior-related lifestyle patterns (Leisure screen time [LST], Sedentary commuting, Sedentary behavior at work). We used inverse variance weighted (IVW), weighted median and MR-Egger for the analysis of Mendelian randomization, followed by sensitivity tests with the Cochran Q test, MR-Egger intercepts analysis and MR-PRESSO. RESULTS: A causal relationship was found between LST and acute pancreatitis based on IVW analysis (odds ratios [OR] = 1.38, corresponding 95% confidence intervals [CI] = 1.16–1.64, p = 0.0002) and there were no causal relationships between physical activity/sedentary behavior and chronic pancreatitis. Sensitivity analysis showed no pleiotropy and heterogeneity of the results. CONCLUSIONS: Results show that reducing LST contributes to the prevention of acute pancreatitis, thereby reducing the health burden associated with it. |
format | Online Article Text |
id | pubmed-10355380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-103553802023-07-20 Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study Ling, Ruiqi Liang, Juan Mo, Shaojian Qi, Jiabao Fu, Xifeng Tian, Yanzhang PLoS One Research Article BACKGROUND: Although observational studies have shown that physical activity is a protective factor for acute pancreatitis, the causal associations between PA/ sedentary behavior and acute pancreatitis (AP) and chronic pancreatitis (CP) remain unclear. METHODS: We used Mendelian randomization as a strategy to assess the causalities between exposures and outcomes by simulating randomized experiments with genetic variation. The collected genetic variants data of physical activity were from UK Biobank, the data on sedentary behavior were also from UK Biobank, and both of them could be found in the GWAS catalog, and the data on AP and CP were from FinnGen. There were three physical activity related activity patterns (moderate to vigorous physical activity [MVPA], accelerometer-based physical activity with average acceleration, [AccAve] and accelerometer-based physical activity with accelerations >425 milli-gravities, [Acc425]) and three sedentary behavior-related lifestyle patterns (Leisure screen time [LST], Sedentary commuting, Sedentary behavior at work). We used inverse variance weighted (IVW), weighted median and MR-Egger for the analysis of Mendelian randomization, followed by sensitivity tests with the Cochran Q test, MR-Egger intercepts analysis and MR-PRESSO. RESULTS: A causal relationship was found between LST and acute pancreatitis based on IVW analysis (odds ratios [OR] = 1.38, corresponding 95% confidence intervals [CI] = 1.16–1.64, p = 0.0002) and there were no causal relationships between physical activity/sedentary behavior and chronic pancreatitis. Sensitivity analysis showed no pleiotropy and heterogeneity of the results. CONCLUSIONS: Results show that reducing LST contributes to the prevention of acute pancreatitis, thereby reducing the health burden associated with it. Public Library of Science 2023-07-19 /pmc/articles/PMC10355380/ /pubmed/37467250 http://dx.doi.org/10.1371/journal.pone.0287810 Text en © 2023 Ling et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ling, Ruiqi Liang, Juan Mo, Shaojian Qi, Jiabao Fu, Xifeng Tian, Yanzhang Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study |
title | Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study |
title_full | Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study |
title_fullStr | Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study |
title_full_unstemmed | Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study |
title_short | Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study |
title_sort | physical activity, sedentary behavior and pancreatitis risk: mendelian randomization study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355380/ https://www.ncbi.nlm.nih.gov/pubmed/37467250 http://dx.doi.org/10.1371/journal.pone.0287810 |
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