Targeting AAV vectors to the central nervous system by engineering capsid–receptor interactions that enable crossing of the blood–brain barrier

Viruses have evolved the ability to bind and enter cells through interactions with a wide variety of cell macromolecules. We engineered peptide-modified adeno-associated virus (AAV) capsids that transduce the brain through the introduction of de novo interactions with 2 proteins expressed on the mou...

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Detalles Bibliográficos
Autores principales: Huang, Qin, Chen, Albert T., Chan, Ken Y., Sorensen, Hikari, Barry, Andrew J., Azari, Bahar, Zheng, Qingxia, Beddow, Thomas, Zhao, Binhui, Tobey, Isabelle G., Moncada-Reid, Cynthia, Eid, Fatma-Elzahraa, Walkey, Christopher J., Ljungberg, M. Cecilia, Lagor, William R., Heaney, Jason D., Chan, Yujia A., Deverman, Benjamin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Methods and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355383/
https://www.ncbi.nlm.nih.gov/pubmed/37467291
http://dx.doi.org/10.1371/journal.pbio.3002112

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