An acidic microenvironment in Tuberculosis increases extracellular matrix degradation by regulating macrophage inflammatory responses

Mycobacterium tuberculosis (M.tb) infection causes marked tissue inflammation leading to lung destruction and morbidity. The inflammatory extracellular microenvironment is acidic, however the effect of this acidosis on the immune response to M.tb is unknown. Using RNA-seq we show that acidosis produ...

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Detalles Bibliográficos
Autores principales: Whittington, Ashley M., Turner, Frances S., Baark, Friedrich, Templeman, Sam, Kirwan, Daniela E., Roufosse, Candice, Krishnan, Nitya, Robertson, Brian D., Chong, Deborah L. W., Porter, Joanna C., Gilman, Robert H., Friedland, Jon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355421/
https://www.ncbi.nlm.nih.gov/pubmed/37418488
http://dx.doi.org/10.1371/journal.ppat.1011495

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