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Physiological aging in India: The role of the epidemiological transition

We construct a cohort-based frailty index from age-related health deficits to investigate physiological aging in India over the period 1990-2019. During this period, the Indian states underwent at different speeds the epidemiological transition and experienced unprecedented economic growth. We show...

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Detalles Bibliográficos
Autores principales: Krenz, Astrid, Strulik, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355452/
https://www.ncbi.nlm.nih.gov/pubmed/37467173
http://dx.doi.org/10.1371/journal.pone.0287259
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author Krenz, Astrid
Strulik, Holger
author_facet Krenz, Astrid
Strulik, Holger
author_sort Krenz, Astrid
collection PubMed
description We construct a cohort-based frailty index from age-related health deficits to investigate physiological aging in India over the period 1990-2019. During this period, the Indian states underwent at different speeds the epidemiological transition and experienced unprecedented economic growth. We show that the rate of physiological aging remained remarkably stable to the changing environment. Age-related health deficits increased by about 3 percent per year of age with little variation across states, ages, cohorts, and over time. We find that, with advancing epidemiological transition, health deficits for given age declined at the individual level (within states and within cohorts). Across cohorts born between 1900 and 1995, we show that, for given age, health deficits are higher for later-born cohorts until birth years around 1940 and remained trendless afterwards. We propose a selection-based theory of aging during the epidemiological transition that explains these facts.
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spelling pubmed-103554522023-07-20 Physiological aging in India: The role of the epidemiological transition Krenz, Astrid Strulik, Holger PLoS One Research Article We construct a cohort-based frailty index from age-related health deficits to investigate physiological aging in India over the period 1990-2019. During this period, the Indian states underwent at different speeds the epidemiological transition and experienced unprecedented economic growth. We show that the rate of physiological aging remained remarkably stable to the changing environment. Age-related health deficits increased by about 3 percent per year of age with little variation across states, ages, cohorts, and over time. We find that, with advancing epidemiological transition, health deficits for given age declined at the individual level (within states and within cohorts). Across cohorts born between 1900 and 1995, we show that, for given age, health deficits are higher for later-born cohorts until birth years around 1940 and remained trendless afterwards. We propose a selection-based theory of aging during the epidemiological transition that explains these facts. Public Library of Science 2023-07-19 /pmc/articles/PMC10355452/ /pubmed/37467173 http://dx.doi.org/10.1371/journal.pone.0287259 Text en © 2023 Krenz, Strulik https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Krenz, Astrid
Strulik, Holger
Physiological aging in India: The role of the epidemiological transition
title Physiological aging in India: The role of the epidemiological transition
title_full Physiological aging in India: The role of the epidemiological transition
title_fullStr Physiological aging in India: The role of the epidemiological transition
title_full_unstemmed Physiological aging in India: The role of the epidemiological transition
title_short Physiological aging in India: The role of the epidemiological transition
title_sort physiological aging in india: the role of the epidemiological transition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355452/
https://www.ncbi.nlm.nih.gov/pubmed/37467173
http://dx.doi.org/10.1371/journal.pone.0287259
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