Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing

BACKGROUND: Central nervous system (CNS) cancer is the 10th leading cause of cancer-associated deaths for adults, but the leading cause in pediatric patients and young adults. The variety and complexity of histologic subtypes can lead to diagnostic errors. DNA methylation is an epigenetic modificati...

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Detalles Bibliográficos
Autores principales: Galbraith, Kristyn, Vasudevaraja, Varshini, Serrano, Jonathan, Shen, Guomiao, Tran, Ivy, Abdallat, Nancy, Wen, Mandisa, Patel, Seema, Movahed-Ezazi, Misha, Faustin, Arline, Spino-Keeton, Marissa, Roberts, Leah Geiser, Maloku, Ekrem, Drexler, Steven A, Liechty, Benjamin L, Pisapia, David, Krasnozhen-Ratush, Olga, Rosenblum, Marc, Shroff, Seema, Boué, Daniel R, Davidson, Christian, Mao, Qinwen, Suchi, Mariko, North, Paula, Hopp, Amanda, Segura, Annette, Jarzembowski, Jason A, Parsons, Lauren, Johnson, Mahlon D, Mobley, Bret, Samore, Wesley, McGuone, Declan, Gopal, Pallavi P, Canoll, Peter D, Horbinski, Craig, Fullmer, Joseph M, Farooqi, Midhat S, Gokden, Murat, Wadhwani, Nitin R, Richardson, Timothy E, Umphlett, Melissa, Tsankova, Nadejda M, DeWitt, John C, Sen, Chandra, Placantonakis, Dimitris G, Pacione, Donato, Wisoff, Jeffrey H, Teresa Hidalgo, Eveline, Harter, David, William, Christopher M, Cordova, Christine, Kurz, Sylvia C, Barbaro, Marissa, Orringer, Daniel A, Karajannis, Matthias A, Sulman, Erik P, Gardner, Sharon L, Zagzag, David, Tsirigos, Aristotelis, Allen, Jeffrey C, Golfinos, John G, Snuderl, Matija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355794/
https://www.ncbi.nlm.nih.gov/pubmed/37476329
http://dx.doi.org/10.1093/noajnl/vdad076

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