Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson’s disease

Mutations in the E3 ubiquitin ligase parkin are the most common cause of early-onset Parkinson’s disease (PD). Although parkin modulates mitochondrial and endolysosomal homeostasis during cellular stress, whether parkin regulates mitochondrial and lysosomal cross-talk under physiologic conditions re...

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Detalles Bibliográficos
Autores principales: Peng, Wesley, Schröder, Leonie F., Song, Pingping, Wong, Yvette C., Krainc, Dimitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355824/
https://www.ncbi.nlm.nih.gov/pubmed/37467322
http://dx.doi.org/10.1126/sciadv.adh3347

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