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TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells

Chimeric antigen receptor (CAR) T cell therapy is used in treating human hematological malignancies, but its efficacy is limited by T cell exhaustion (T(EX)). T(EX) arises at the expense of central memory T cells (T(CM)), which exhibit robust antitumor efficacy. Reduction of the TET2 gene led to inc...

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Detalles Bibliográficos
Autores principales:	Collins, Sierra M., Alexander, Katherine A., Lundh, Stefan, Dimitri, Alexander J., Zhang, Zhen, Good, Charly R., Fraietta, Joseph A., Berger, Shelley L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355826/ https://www.ncbi.nlm.nih.gov/pubmed/37467321 http://dx.doi.org/10.1126/sciadv.adh2605

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