Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function

The gelatinases, matrix metalloproteinase 2 (MMP-2) and MMP-9, are key for leukocyte penetration of the brain parenchymal border in neuroinflammation and the functional integrity of this barrier; however, it is unclear which MMP substrates are involved. Using a tailored, sensitive, label-free mass s...

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Detalles Bibliográficos
Autores principales: Burmeister, Miriam, Fraunenstein, Annika, Kahms, Martin, Arends, Laura, Gerwien, Hanna, Deshpande, Tushar, Kuhlmann, Tanja, Gross, Catharina C., Naik, Venu N., Wiendl, Heinz, Klingauf, Juergen, Meissner, Felix, Sorokin, Lydia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355830/
https://www.ncbi.nlm.nih.gov/pubmed/37467333
http://dx.doi.org/10.1126/sciadv.adg0686

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