d-lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma

The polarization of tumor-associated macrophages (TAMs) from M2 to M1 phenotype demonstrates great potential for remodeling the immunosuppressive tumor microenvironment (TME) of hepatocellular carcinoma (HCC). d-lactate (DL; a gut microbiome metabolite) acts as an endogenous immunomodulatory agent t...

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Detalles Bibliográficos
Autores principales: Han, Shulan, Bao, Xueying, Zou, Yifang, Wang, Lingzhi, Li, Yutong, Yang, Leilei, Liao, Anqi, Zhang, Xuemei, Jiang, Xin, Liang, Di, Dai, Yun, Zheng, Qing-Chuan, Yu, Zhuo, Guo, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355835/
https://www.ncbi.nlm.nih.gov/pubmed/37467325
http://dx.doi.org/10.1126/sciadv.adg2697

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