The opening dynamics of the lateral gate regulates the activity of rhomboid proteases

Rhomboid proteases hydrolyze substrate helices within the lipid bilayer to release soluble domains from the membrane. Here, we investigate the mechanism of activity regulation for this unique but wide-spread protein family. In the model rhomboid GlpG, a lateral gate formed by transmembrane helices T...

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Detalles Bibliográficos
Autores principales: Bohg, Claudia, Öster, Carl, Türkaydin, Berke, Lisurek, Michael, Sanchez-Carranza, Pascal, Lange, Sascha, Utesch, Tillmann, Sun, Han, Lange, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355837/
https://www.ncbi.nlm.nih.gov/pubmed/37467320
http://dx.doi.org/10.1126/sciadv.adh3858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355837/
https://www.ncbi.nlm.nih.gov/pubmed/37467320
http://dx.doi.org/10.1126/sciadv.adh3858

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