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Silencing of PKG1 Gene Mimics Effect of Aging and Sensitizes Rat Vascular Smooth Muscle Cells to Cardiotonic Steroids: Impact on Fibrosis and Salt Sensitivity

BACKGROUND: Marinobufagenin, NKA (Na/K‐ATPase) inhibitor, causes vasoconstriction and induces fibrosis via inhibition of Fli1 (Friend leukemia integration‐1), a negative regulator of collagen synthesis. In vascular smooth muscle cells (VSMC), ANP (atrial natriuretic peptide), via a cGMP/PKG1 (protei...

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Detalles Bibliográficos
Autores principales:	Fedorova, Olga V., Shilova, Victoria Y., Zernetkina, Valentina, Juhasz, Ondrej, Wei, Wen, Lakatta, Edward G., Bagrov, Alexei Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356040/ https://www.ncbi.nlm.nih.gov/pubmed/37301747 http://dx.doi.org/10.1161/JAHA.122.028768

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