Electron Leak From the Mitochondrial Electron Transport Chain Complex I at Site I(Q) Is Crucial for Oxygen Sensing in Rabbit and Human Ductus Arteriosus

BACKGROUND: As partial pressure of oxygen (pO(2)) rises with the first breath, the ductus arteriosus (DA) constricts, diverting blood flow to the pulmonary circulation. The DA's O(2) sensor resides within smooth muscle cells. The DA smooth muscle cells’ mitochondrial electron transport chain (E...

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Detalles Bibliográficos
Autores principales: Read, Austin D., Bentley, Rachel E. T., Martin, Ashley Y., Mewburn, Jeffrey D., Alizadeh, Elahe, Wu, Danchen, Lima, Patricia D. A., Dunham‐Snary, Kimberly J., Thébaud, Bernard, Sharp, Willard, Archer, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356098/
https://www.ncbi.nlm.nih.gov/pubmed/37345832
http://dx.doi.org/10.1161/JAHA.122.029131

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