Cargando…

Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study

OBJECTIVE: To describe and compare the clinical characteristics and outcomes of patients admitted to intensive care units during the first and second waves of the COVID-19 pandemic. METHODS: In this retrospective single-center cohort study, data were retrieved from the Epimed Monitor System; all adu...

Descripción completa

Detalles Bibliográficos
Autores principales: Corrêa, Thiago Domingos, Midega, Thais Dias, Cordioli, Ricardo Luiz, Barbas, Carmen Silvia Valente, Rabello, Roberto, da Silva, Bruno Caldin, Silva, Moacyr, Nawa, Ricardo Kenji, de Carvalho, Fabrício Rodrigues Torres, de Matos, Gustavo Faissol Janot, Lucinio, Neide Marcela, Rodrigues, Rodrigo Dias, Eid, Raquel Afonso Caserta, Bravim, Bruno de Arruda, Pereira, Adriano José, dos Santos, Bento Fortunato Cardoso, Pinho, João Renato Rebello, Pardini, Andreia, Teich, Vanessa Damazio, Laselva, Claudia Regina, Cendoroglo, Miguel, Klajner, Sidney, Ferraz, Leonardo José Rolim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356126/
https://www.ncbi.nlm.nih.gov/pubmed/37493832
http://dx.doi.org/10.31744/einstein_journal/2023AO0233
_version_ 1785075202783182848
author Corrêa, Thiago Domingos
Midega, Thais Dias
Cordioli, Ricardo Luiz
Barbas, Carmen Silvia Valente
Rabello, Roberto
da Silva, Bruno Caldin
Silva, Moacyr
Nawa, Ricardo Kenji
de Carvalho, Fabrício Rodrigues Torres
de Matos, Gustavo Faissol Janot
Lucinio, Neide Marcela
Rodrigues, Rodrigo Dias
Eid, Raquel Afonso Caserta
Bravim, Bruno de Arruda
Pereira, Adriano José
dos Santos, Bento Fortunato Cardoso
Pinho, João Renato Rebello
Pardini, Andreia
Teich, Vanessa Damazio
Laselva, Claudia Regina
Cendoroglo, Miguel
Klajner, Sidney
Ferraz, Leonardo José Rolim
author_facet Corrêa, Thiago Domingos
Midega, Thais Dias
Cordioli, Ricardo Luiz
Barbas, Carmen Silvia Valente
Rabello, Roberto
da Silva, Bruno Caldin
Silva, Moacyr
Nawa, Ricardo Kenji
de Carvalho, Fabrício Rodrigues Torres
de Matos, Gustavo Faissol Janot
Lucinio, Neide Marcela
Rodrigues, Rodrigo Dias
Eid, Raquel Afonso Caserta
Bravim, Bruno de Arruda
Pereira, Adriano José
dos Santos, Bento Fortunato Cardoso
Pinho, João Renato Rebello
Pardini, Andreia
Teich, Vanessa Damazio
Laselva, Claudia Regina
Cendoroglo, Miguel
Klajner, Sidney
Ferraz, Leonardo José Rolim
author_sort Corrêa, Thiago Domingos
collection PubMed
description OBJECTIVE: To describe and compare the clinical characteristics and outcomes of patients admitted to intensive care units during the first and second waves of the COVID-19 pandemic. METHODS: In this retrospective single-center cohort study, data were retrieved from the Epimed Monitor System; all adult patients admitted to the intensive care unit between March 4, 2020, and October 1, 2021, were included in the study. We compared the clinical characteristics and outcomes of patients admitted to the intensive care unit of a quaternary private hospital in São Paulo, Brazil, during the first (May 1, 2020, to August 31, 2020) and second (March 1, 2021, to June 30, 2021) waves of the COVID-19 pandemic. RESULTS: In total, 1,427 patients with COVID-19 were admitted to the intensive care unit during the first (421 patients) and second (1,006 patients) waves. Compared with the first wave group [median (IQR)], the second wave group was younger [57 (46-70) versus 67 (52-80) years; p<0.001], had a lower SAPS 3 Score [45 (42-52) versus 49 (43-57); p<0.001], lower SOFA Score on intensive care unit admission [3 (1-6) versus 4 (2-6); p=0.018], lower Charlson Comorbidity Index [0 (0-1) versus 1 (0-2); p<0.001], and were less frequently frail (10.4% versus 18.1%; p<0.001). The second wave group used more noninvasive ventilation (81.3% versus 53.4%; p<0.001) and high-flow nasal cannula (63.2% versus 23.0%; p<0.001) during their intensive care unit stay. The intensive care unit (11.3% versus 10.5%; p=0.696) and in-hospital mortality (12.3% versus 12.1%; p=0.998) rates did not differ between both waves. CONCLUSION: In the first and second waves, patients with severe COVID-19 exhibited similar mortality rates and need for invasive organ support, despite the second wave group being younger and less severely ill at the time of intensive care unit admission.
format Online
Article
Text
id pubmed-10356126
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Instituto Israelita de Ensino e Pesquisa Albert Einstein
record_format MEDLINE/PubMed
spelling pubmed-103561262023-07-20 Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study Corrêa, Thiago Domingos Midega, Thais Dias Cordioli, Ricardo Luiz Barbas, Carmen Silvia Valente Rabello, Roberto da Silva, Bruno Caldin Silva, Moacyr Nawa, Ricardo Kenji de Carvalho, Fabrício Rodrigues Torres de Matos, Gustavo Faissol Janot Lucinio, Neide Marcela Rodrigues, Rodrigo Dias Eid, Raquel Afonso Caserta Bravim, Bruno de Arruda Pereira, Adriano José dos Santos, Bento Fortunato Cardoso Pinho, João Renato Rebello Pardini, Andreia Teich, Vanessa Damazio Laselva, Claudia Regina Cendoroglo, Miguel Klajner, Sidney Ferraz, Leonardo José Rolim Einstein (Sao Paulo) Original Article OBJECTIVE: To describe and compare the clinical characteristics and outcomes of patients admitted to intensive care units during the first and second waves of the COVID-19 pandemic. METHODS: In this retrospective single-center cohort study, data were retrieved from the Epimed Monitor System; all adult patients admitted to the intensive care unit between March 4, 2020, and October 1, 2021, were included in the study. We compared the clinical characteristics and outcomes of patients admitted to the intensive care unit of a quaternary private hospital in São Paulo, Brazil, during the first (May 1, 2020, to August 31, 2020) and second (March 1, 2021, to June 30, 2021) waves of the COVID-19 pandemic. RESULTS: In total, 1,427 patients with COVID-19 were admitted to the intensive care unit during the first (421 patients) and second (1,006 patients) waves. Compared with the first wave group [median (IQR)], the second wave group was younger [57 (46-70) versus 67 (52-80) years; p<0.001], had a lower SAPS 3 Score [45 (42-52) versus 49 (43-57); p<0.001], lower SOFA Score on intensive care unit admission [3 (1-6) versus 4 (2-6); p=0.018], lower Charlson Comorbidity Index [0 (0-1) versus 1 (0-2); p<0.001], and were less frequently frail (10.4% versus 18.1%; p<0.001). The second wave group used more noninvasive ventilation (81.3% versus 53.4%; p<0.001) and high-flow nasal cannula (63.2% versus 23.0%; p<0.001) during their intensive care unit stay. The intensive care unit (11.3% versus 10.5%; p=0.696) and in-hospital mortality (12.3% versus 12.1%; p=0.998) rates did not differ between both waves. CONCLUSION: In the first and second waves, patients with severe COVID-19 exhibited similar mortality rates and need for invasive organ support, despite the second wave group being younger and less severely ill at the time of intensive care unit admission. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2023-07-06 /pmc/articles/PMC10356126/ /pubmed/37493832 http://dx.doi.org/10.31744/einstein_journal/2023AO0233 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Corrêa, Thiago Domingos
Midega, Thais Dias
Cordioli, Ricardo Luiz
Barbas, Carmen Silvia Valente
Rabello, Roberto
da Silva, Bruno Caldin
Silva, Moacyr
Nawa, Ricardo Kenji
de Carvalho, Fabrício Rodrigues Torres
de Matos, Gustavo Faissol Janot
Lucinio, Neide Marcela
Rodrigues, Rodrigo Dias
Eid, Raquel Afonso Caserta
Bravim, Bruno de Arruda
Pereira, Adriano José
dos Santos, Bento Fortunato Cardoso
Pinho, João Renato Rebello
Pardini, Andreia
Teich, Vanessa Damazio
Laselva, Claudia Regina
Cendoroglo, Miguel
Klajner, Sidney
Ferraz, Leonardo José Rolim
Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study
title Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study
title_full Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study
title_fullStr Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study
title_full_unstemmed Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study
title_short Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study
title_sort clinical characteristics and outcomes of patients with covid-19 admitted to the intensive care unit during the first and second waves of the pandemic in brazil: a single-center retrospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356126/
https://www.ncbi.nlm.nih.gov/pubmed/37493832
http://dx.doi.org/10.31744/einstein_journal/2023AO0233
work_keys_str_mv AT correathiagodomingos clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT midegathaisdias clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT cordioliricardoluiz clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT barbascarmensilviavalente clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT rabelloroberto clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT dasilvabrunocaldin clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT silvamoacyr clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT nawaricardokenji clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT decarvalhofabriciorodriguestorres clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT dematosgustavofaissoljanot clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT lucinioneidemarcela clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT rodriguesrodrigodias clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT eidraquelafonsocaserta clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT bravimbrunodearruda clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT pereiraadrianojose clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT dossantosbentofortunatocardoso clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT pinhojoaorenatorebello clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT pardiniandreia clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT teichvanessadamazio clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT laselvaclaudiaregina clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT cendoroglomiguel clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT klajnersidney clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy
AT ferrazleonardojoserolim clinicalcharacteristicsandoutcomesofpatientswithcovid19admittedtotheintensivecareunitduringthefirstandsecondwavesofthepandemicinbrazilasinglecenterretrospectivecohortstudy