Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin

Although the role of the Wnt pathway in colon carcinogenesis has been described previously, it has been recently demonstrated that Wnt signaling originates from highly dynamic nano-assemblies at the plasma membrane. However, little is known regarding the role of oncogenic APC in reshaping Wnt nanodo...

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Detalles Bibliográficos
Autores principales: Erazo-Oliveras, Alfredo, Muñoz-Vega, Mónica, Mlih, Mohamed, Thiriveedi, Venkataramana, Salinas, Michael L., Rivera-Rodríguez, Jaileen M., Kim, Eunjoo, Wright, Rachel C., Wang, Xiaoli, Landrock, Kerstin K., Goldsby, Jennifer S., Mullens, Destiny A., Roper, Jatin, Karpac, Jason, Chapkin, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356786/
https://www.ncbi.nlm.nih.gov/pubmed/37468468
http://dx.doi.org/10.1038/s41467-023-39640-w

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