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Effect of angiotensin II on irradiation exacerbated decompression sickness
In some complicated situations, decompression sickness (DCS) combined with other injuries, such as irradiation, will seriously endanger life safety. However, it is still unclear whether irradiation will increase the incidence of DCS. This study was designed to investigate the damage effects of irrad...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356789/ https://www.ncbi.nlm.nih.gov/pubmed/37468556 http://dx.doi.org/10.1038/s41598-023-38752-z |
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author | Fan, Jie-Fu Wang, Yang-Kai Liu, Min Liu, Guang-Sheng Min, Tian-Jiao Chen, Rui-Yong He, Ying |
author_facet | Fan, Jie-Fu Wang, Yang-Kai Liu, Min Liu, Guang-Sheng Min, Tian-Jiao Chen, Rui-Yong He, Ying |
author_sort | Fan, Jie-Fu |
collection | PubMed |
description | In some complicated situations, decompression sickness (DCS) combined with other injuries, such as irradiation, will seriously endanger life safety. However, it is still unclear whether irradiation will increase the incidence of DCS. This study was designed to investigate the damage effects of irradiation on decompression injury and the underlying mechanism. Sprague–Dawley rats were exposed to irradiation followed by hyperbaric decompressing and the mortality and decompression symptoms were observed. Lung tissue and bronchoalveolar lavage fluid were collected to detect the lung lesion, inflammation response, activity of the angiotensin system, oxidative stress, and relative signal pathway by multiple methods, including Q-PCR, western blot, and ELISA. As a result, pre-exposure to radiation significantly exacerbated disease outcomes and lung lesions of DCS. Mechanically, the up-regulation of angiotensin-converting enzyme expression and angiotensin II levels was responsible for the exacerbated DCS and lung lesions caused by predisposing irradiation exposure. Oxidative stress and PI3K/AKT signal pathway activation in pulmonary tissue were enhanced after irradiation plus decompression treatment. In conclusion, our results suggested that irradiation could exacerbate lung injury and the outcomes of DCS by activating the angiotensin system, which included eliciting oxidative stress and activation of the PI3K/AKT signal pathway. |
format | Online Article Text |
id | pubmed-10356789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103567892023-07-21 Effect of angiotensin II on irradiation exacerbated decompression sickness Fan, Jie-Fu Wang, Yang-Kai Liu, Min Liu, Guang-Sheng Min, Tian-Jiao Chen, Rui-Yong He, Ying Sci Rep Article In some complicated situations, decompression sickness (DCS) combined with other injuries, such as irradiation, will seriously endanger life safety. However, it is still unclear whether irradiation will increase the incidence of DCS. This study was designed to investigate the damage effects of irradiation on decompression injury and the underlying mechanism. Sprague–Dawley rats were exposed to irradiation followed by hyperbaric decompressing and the mortality and decompression symptoms were observed. Lung tissue and bronchoalveolar lavage fluid were collected to detect the lung lesion, inflammation response, activity of the angiotensin system, oxidative stress, and relative signal pathway by multiple methods, including Q-PCR, western blot, and ELISA. As a result, pre-exposure to radiation significantly exacerbated disease outcomes and lung lesions of DCS. Mechanically, the up-regulation of angiotensin-converting enzyme expression and angiotensin II levels was responsible for the exacerbated DCS and lung lesions caused by predisposing irradiation exposure. Oxidative stress and PI3K/AKT signal pathway activation in pulmonary tissue were enhanced after irradiation plus decompression treatment. In conclusion, our results suggested that irradiation could exacerbate lung injury and the outcomes of DCS by activating the angiotensin system, which included eliciting oxidative stress and activation of the PI3K/AKT signal pathway. Nature Publishing Group UK 2023-07-19 /pmc/articles/PMC10356789/ /pubmed/37468556 http://dx.doi.org/10.1038/s41598-023-38752-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Fan, Jie-Fu Wang, Yang-Kai Liu, Min Liu, Guang-Sheng Min, Tian-Jiao Chen, Rui-Yong He, Ying Effect of angiotensin II on irradiation exacerbated decompression sickness |
title | Effect of angiotensin II on irradiation exacerbated decompression sickness |
title_full | Effect of angiotensin II on irradiation exacerbated decompression sickness |
title_fullStr | Effect of angiotensin II on irradiation exacerbated decompression sickness |
title_full_unstemmed | Effect of angiotensin II on irradiation exacerbated decompression sickness |
title_short | Effect of angiotensin II on irradiation exacerbated decompression sickness |
title_sort | effect of angiotensin ii on irradiation exacerbated decompression sickness |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356789/ https://www.ncbi.nlm.nih.gov/pubmed/37468556 http://dx.doi.org/10.1038/s41598-023-38752-z |
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