SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma

Ewing sarcoma (ES), which is characterized by the presence of oncogenic fusion proteins such as EWS/FLI1, is an aggressive pediatric malignancy with a high rate of early dissemination and poor outcome after distant spread. Here we demonstrate that the SIX1 homeoprotein, which enhances metastasis in...

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Detalles Bibliográficos
Autores principales: Hughes, Connor J., Fields, Kaiah M., Danis, Etienne P., Hsu, Jessica Y., Neelakantan, Deepika, Vincent, Melanie Y., Gustafson, Annika L., Oliphant, Michael J., Sreekanth, Varsha, Zaberezhnyy, Vadym, Costello, James C., Jedlicka, Paul, Ford, Heide L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356808/
https://www.ncbi.nlm.nih.gov/pubmed/37468459
http://dx.doi.org/10.1038/s41467-023-39945-w

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