Activation of SARS-CoV-2 by trypsin-like proteases in the clinical specimens of patients with COVID-19

SARS-CoV-2 enters host cells through the angiotensin converting enzyme 2 (ACE2) receptor and/or transmembrane protease, serine 2 (TMPRSS2). In this study, we investigated whether proteases increased SARS-CoV-2 infectivity using pseudotyped viruses and clinical specimens from patients with COVID-19....

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Detalles Bibliográficos
Autores principales: Yamazaki, Emiko, Yazawa, Shunsuke, Shimada, Takahisa, Tamura, Kosuke, Saga, Yumiko, Itamochi, Masae, Inasaki, Noriko, Hasegawa, Sumiyo, Morinaga, Yoshitomo, Oishi, Kazunori, Tani, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356862/
https://www.ncbi.nlm.nih.gov/pubmed/37468582
http://dx.doi.org/10.1038/s41598-023-38757-8

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