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Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc

Pathological mineralization of intervertebral disc is debilitating and painful and linked to disc degeneration in a subset of human patients. An adenosine triphosphate efflux transporter, progressive ankylosis (ANK) is a regulator of extracellular inorganic pyrophosphate levels and plays an importan...

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Detalles Bibliográficos
Autores principales:	Ohnishi, Takashi, Tran, Victoria, Sao, Kimheak, Ramteke, Pranay, Querido, William, Barve, Ruteja A., van de Wetering, Koen, Risbud, Makarand V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356955/ https://www.ncbi.nlm.nih.gov/pubmed/37468461 http://dx.doi.org/10.1038/s41419-023-05893-y

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