Loss of TSC1 in secondary angiosarcoma of the breast

KEY CLINICAL MESSAGE: Post‐radiation angiosarcoma of the breast is a rare complication associated with a poor prognosis. This case reports the first loss of function mutation in TSC1 in breast radiation‐induced angiosarcoma and illustrates the utility of evaluating these markers to identify potentia...

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Detalles Bibliográficos
Autores principales: Rose, Lucy, Owusu‐Brackett, Nicci, Moore, Stephen, Oppong, Bridget
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357003/
https://www.ncbi.nlm.nih.gov/pubmed/37484752
http://dx.doi.org/10.1002/ccr3.7539
Descripción
Sumario:KEY CLINICAL MESSAGE: Post‐radiation angiosarcoma of the breast is a rare complication associated with a poor prognosis. This case reports the first loss of function mutation in TSC1 in breast radiation‐induced angiosarcoma and illustrates the utility of evaluating these markers to identify potential therapeutic targets. ABSTRACT: Post‐radiation angiosarcoma of the breast is rare and associated with a poor prognosis. This case presents the first loss of function mutation in TSC1 in breast radiation‐induced angiosarcoma. Evaluation of these markers can aid in identifying potential therapeutic targets.

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