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Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso

AIM: Glaucoma is a group of degenerative diseases of the optic nerve whose predisposing factors may be genetic. The objective of this study was to estimate the frequency of the Glu323Lys mutation as a genetic risk factor for glaucoma. MATERIALS AND METHODS: A cross-sectional study over 6 months from...

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Autores principales: Traoré, Lassina, Sanou, Jérôme, Bakyono, Bélélé S, Zoure, Abdou A, Zohoncon, Théodora M, Sombié, Hermann K, Yonli, Albert T, Meda-Hien, Guertrude, Tibiri, Ezechiel B, Djigma, Florencia W, Simpore, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357018/
https://www.ncbi.nlm.nih.gov/pubmed/37485465
http://dx.doi.org/10.5005/jp-journals-10078-1403
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author Traoré, Lassina
Sanou, Jérôme
Bakyono, Bélélé S
Zoure, Abdou A
Zohoncon, Théodora M
Sombié, Hermann K
Yonli, Albert T
Meda-Hien, Guertrude
Tibiri, Ezechiel B
Djigma, Florencia W
Simpore, Jacques
author_facet Traoré, Lassina
Sanou, Jérôme
Bakyono, Bélélé S
Zoure, Abdou A
Zohoncon, Théodora M
Sombié, Hermann K
Yonli, Albert T
Meda-Hien, Guertrude
Tibiri, Ezechiel B
Djigma, Florencia W
Simpore, Jacques
author_sort Traoré, Lassina
collection PubMed
description AIM: Glaucoma is a group of degenerative diseases of the optic nerve whose predisposing factors may be genetic. The objective of this study was to estimate the frequency of the Glu323Lys mutation as a genetic risk factor for glaucoma. MATERIALS AND METHODS: A cross-sectional study over 6 months from October 2020 to March 2021 in Ouagadougou, Burkina Faso. A total of 89 samples of patients with primary open-angle glaucoma (POAG) were collected. The frequency of the Glu323Lys mutation of the myocilin, trabecular meshwork inducible glucocorticoid response (TIGR/MYOC) gene by polymerase chain reaction (PCR)—restriction fragment length polymorphism. RESULTS: In glaucoma patients, only homozygous nonmutated guanine-guanine (GG) and heterozygous mutated adenine-guanine (AG) genotypes were found in 96.63 and 3.37% of cases, respectively. Around 69.66% of patients had a family history of glaucoma, 28.09% had a history of hypertension, and 7.86% had a history of diabetes. CONCLUSION: The frequency of the Glu323Lys mutation of the TIGR/MYOC gene was 3.37% in the glaucoma population in Ouagadougou. A case-control study is necessary to know the contribution of the Glu323Lys mutation as a genetic risk factor for glaucoma in our study population. CLINICAL SIGNIFICANCE: This study constituted the beginning of genetic investigations of glaucoma in our context and showed a low Glu323Lys mutation. HOW TO CITE THIS ARTICLE: Traoré L, Sanou J, Bakyono BS, et al. Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso. J Curr Glaucoma Pract 2023;17(2):79-84.
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spelling pubmed-103570182023-07-21 Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso Traoré, Lassina Sanou, Jérôme Bakyono, Bélélé S Zoure, Abdou A Zohoncon, Théodora M Sombié, Hermann K Yonli, Albert T Meda-Hien, Guertrude Tibiri, Ezechiel B Djigma, Florencia W Simpore, Jacques J Curr Glaucoma Pract Original Article AIM: Glaucoma is a group of degenerative diseases of the optic nerve whose predisposing factors may be genetic. The objective of this study was to estimate the frequency of the Glu323Lys mutation as a genetic risk factor for glaucoma. MATERIALS AND METHODS: A cross-sectional study over 6 months from October 2020 to March 2021 in Ouagadougou, Burkina Faso. A total of 89 samples of patients with primary open-angle glaucoma (POAG) were collected. The frequency of the Glu323Lys mutation of the myocilin, trabecular meshwork inducible glucocorticoid response (TIGR/MYOC) gene by polymerase chain reaction (PCR)—restriction fragment length polymorphism. RESULTS: In glaucoma patients, only homozygous nonmutated guanine-guanine (GG) and heterozygous mutated adenine-guanine (AG) genotypes were found in 96.63 and 3.37% of cases, respectively. Around 69.66% of patients had a family history of glaucoma, 28.09% had a history of hypertension, and 7.86% had a history of diabetes. CONCLUSION: The frequency of the Glu323Lys mutation of the TIGR/MYOC gene was 3.37% in the glaucoma population in Ouagadougou. A case-control study is necessary to know the contribution of the Glu323Lys mutation as a genetic risk factor for glaucoma in our study population. CLINICAL SIGNIFICANCE: This study constituted the beginning of genetic investigations of glaucoma in our context and showed a low Glu323Lys mutation. HOW TO CITE THIS ARTICLE: Traoré L, Sanou J, Bakyono BS, et al. Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso. J Curr Glaucoma Pract 2023;17(2):79-84. Jaypee Brothers Medical Publishers 2023 /pmc/articles/PMC10357018/ /pubmed/37485465 http://dx.doi.org/10.5005/jp-journals-10078-1403 Text en Copyright © 2023; The Author(s). https://creativecommons.org/licenses/by-nc/4.0/© The Author(s). 2023 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Article
Traoré, Lassina
Sanou, Jérôme
Bakyono, Bélélé S
Zoure, Abdou A
Zohoncon, Théodora M
Sombié, Hermann K
Yonli, Albert T
Meda-Hien, Guertrude
Tibiri, Ezechiel B
Djigma, Florencia W
Simpore, Jacques
Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso
title Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso
title_full Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso
title_fullStr Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso
title_full_unstemmed Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso
title_short Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso
title_sort prevalence of glu323lys mutation of the tigr/myoc gene and risk factors amongst primary open-angle glaucoma patients in ouagadougou, burkina faso
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357018/
https://www.ncbi.nlm.nih.gov/pubmed/37485465
http://dx.doi.org/10.5005/jp-journals-10078-1403
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