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Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation

Metabolic disorders including obesity, diabetes and non-alcoholic steatohepatitis are a group of conditions characterised by chronic low-grade inflammation of metabolic tissues. There is now a growing appreciation that various metabolites released from adipose tissue serve as key signalling mediator...

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Autores principales: Duncan, Elaine M., Vita, Luca, Dibnah, Bethany, Hudson, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357040/
https://www.ncbi.nlm.nih.gov/pubmed/37484963
http://dx.doi.org/10.3389/fendo.2023.1197102
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author Duncan, Elaine M.
Vita, Luca
Dibnah, Bethany
Hudson, Brian D.
author_facet Duncan, Elaine M.
Vita, Luca
Dibnah, Bethany
Hudson, Brian D.
author_sort Duncan, Elaine M.
collection PubMed
description Metabolic disorders including obesity, diabetes and non-alcoholic steatohepatitis are a group of conditions characterised by chronic low-grade inflammation of metabolic tissues. There is now a growing appreciation that various metabolites released from adipose tissue serve as key signalling mediators, influencing this interaction with inflammation. G protein-coupled receptors (GPCRs) are the largest family of signal transduction proteins and most historically successful drug targets. The signalling pathways for several key adipose metabolites are mediated through GPCRs expressed both on the adipocytes themselves and on infiltrating macrophages. These include three main groups of GPCRs: the FFA4 receptor, which is activated by long chain free fatty acids; the HCA(2) and HCA(3) receptors, activated by hydroxy carboxylic acids; and the succinate receptor. Understanding the roles these metabolites and their receptors play in metabolic-immune interactions is critical to establishing how these GPCRs may be exploited for the treatment of metabolic disorders.
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spelling pubmed-103570402023-07-21 Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation Duncan, Elaine M. Vita, Luca Dibnah, Bethany Hudson, Brian D. Front Endocrinol (Lausanne) Endocrinology Metabolic disorders including obesity, diabetes and non-alcoholic steatohepatitis are a group of conditions characterised by chronic low-grade inflammation of metabolic tissues. There is now a growing appreciation that various metabolites released from adipose tissue serve as key signalling mediators, influencing this interaction with inflammation. G protein-coupled receptors (GPCRs) are the largest family of signal transduction proteins and most historically successful drug targets. The signalling pathways for several key adipose metabolites are mediated through GPCRs expressed both on the adipocytes themselves and on infiltrating macrophages. These include three main groups of GPCRs: the FFA4 receptor, which is activated by long chain free fatty acids; the HCA(2) and HCA(3) receptors, activated by hydroxy carboxylic acids; and the succinate receptor. Understanding the roles these metabolites and their receptors play in metabolic-immune interactions is critical to establishing how these GPCRs may be exploited for the treatment of metabolic disorders. Frontiers Media S.A. 2023-07-06 /pmc/articles/PMC10357040/ /pubmed/37484963 http://dx.doi.org/10.3389/fendo.2023.1197102 Text en Copyright © 2023 Duncan, Vita, Dibnah and Hudson https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Duncan, Elaine M.
Vita, Luca
Dibnah, Bethany
Hudson, Brian D.
Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation
title Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation
title_full Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation
title_fullStr Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation
title_full_unstemmed Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation
title_short Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation
title_sort metabolite-sensing gpcrs controlling interactions between adipose tissue and inflammation
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357040/
https://www.ncbi.nlm.nih.gov/pubmed/37484963
http://dx.doi.org/10.3389/fendo.2023.1197102
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