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White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia
BACKGROUND: Alzheimer’s disease (AD) and cerebrovascular disease are common, co-existing pathologies in older adults. Whether the effects of cerebrovascular disease and AD biomarkers on cognition are additive or synergistic remains unclear. OBJECTIVE: To examine whether white matter hyperintensity (...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357163/ https://www.ncbi.nlm.nih.gov/pubmed/37302031 http://dx.doi.org/10.3233/JAD-221209 |
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author | Edwards, Lauren Thomas, Kelsey R. Weigand, Alexandra J. Edmonds, Emily C. Clark, Alexandra L. Walker, Kayla S. Brenner, Einat K. Nation, Daniel A. Maillard, Pauline Bondi, Mark W. Bangen, Katherine J. |
author_facet | Edwards, Lauren Thomas, Kelsey R. Weigand, Alexandra J. Edmonds, Emily C. Clark, Alexandra L. Walker, Kayla S. Brenner, Einat K. Nation, Daniel A. Maillard, Pauline Bondi, Mark W. Bangen, Katherine J. |
author_sort | Edwards, Lauren |
collection | PubMed |
description | BACKGROUND: Alzheimer’s disease (AD) and cerebrovascular disease are common, co-existing pathologies in older adults. Whether the effects of cerebrovascular disease and AD biomarkers on cognition are additive or synergistic remains unclear. OBJECTIVE: To examine whether white matter hyperintensity (WMH) volume moderates the independent association between each AD biomarker and cognition. METHODS: In 586 older adults without dementia, linear regressions tested the interaction between amyloid-β (Aβ) positron emission tomography (PET) and WMH volume on cognition, independent of tau-PET. We also tested the interaction between tau-PET and WMH volume on cognition, independent of Aβ-PET. RESULTS: Adjusting for tau-PET, the quadratic effect of WMH interacted with Aβ-PET to impact memory. There was no interaction between either the linear or quadratic effect of WMH and Aβ-PET on executive function. There was no interaction between WMH volume and tau-PET on either cognitive measure. CONCLUSION: Results suggest that cerebrovascular lesions act synergistically with Aβ to affect memory, independent of tau, highlighting the importance of incorporating vascular pathology into biomarker assessment of AD. |
format | Online Article Text |
id | pubmed-10357163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103571632023-07-21 White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia Edwards, Lauren Thomas, Kelsey R. Weigand, Alexandra J. Edmonds, Emily C. Clark, Alexandra L. Walker, Kayla S. Brenner, Einat K. Nation, Daniel A. Maillard, Pauline Bondi, Mark W. Bangen, Katherine J. J Alzheimers Dis Research Article BACKGROUND: Alzheimer’s disease (AD) and cerebrovascular disease are common, co-existing pathologies in older adults. Whether the effects of cerebrovascular disease and AD biomarkers on cognition are additive or synergistic remains unclear. OBJECTIVE: To examine whether white matter hyperintensity (WMH) volume moderates the independent association between each AD biomarker and cognition. METHODS: In 586 older adults without dementia, linear regressions tested the interaction between amyloid-β (Aβ) positron emission tomography (PET) and WMH volume on cognition, independent of tau-PET. We also tested the interaction between tau-PET and WMH volume on cognition, independent of Aβ-PET. RESULTS: Adjusting for tau-PET, the quadratic effect of WMH interacted with Aβ-PET to impact memory. There was no interaction between either the linear or quadratic effect of WMH and Aβ-PET on executive function. There was no interaction between WMH volume and tau-PET on either cognitive measure. CONCLUSION: Results suggest that cerebrovascular lesions act synergistically with Aβ to affect memory, independent of tau, highlighting the importance of incorporating vascular pathology into biomarker assessment of AD. IOS Press 2023-07-18 /pmc/articles/PMC10357163/ /pubmed/37302031 http://dx.doi.org/10.3233/JAD-221209 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Edwards, Lauren Thomas, Kelsey R. Weigand, Alexandra J. Edmonds, Emily C. Clark, Alexandra L. Walker, Kayla S. Brenner, Einat K. Nation, Daniel A. Maillard, Pauline Bondi, Mark W. Bangen, Katherine J. White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia |
title | White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia |
title_full | White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia |
title_fullStr | White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia |
title_full_unstemmed | White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia |
title_short | White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia |
title_sort | white matter hyperintensity volume and amyloid-pet synergistically impact memory independent of tau-pet in older adults without dementia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357163/ https://www.ncbi.nlm.nih.gov/pubmed/37302031 http://dx.doi.org/10.3233/JAD-221209 |
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