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Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature
BACKGROUND: Postural Orthostatic Tachycardia Syndrome (POTS) is a common condition affecting more than 170 people per 100,000 population. However, POTS following COVID-19 vaccination remains a rare reporting in the medical literature. OBJECTIVE: We, herein, summarize and highlight the evidence that...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357168/ https://www.ncbi.nlm.nih.gov/pubmed/37248893 http://dx.doi.org/10.3233/HAB-220013 |
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author | TV, Phu Tran, Thu Thao Hao, Huynh Trung Hau, Nguyen Thi Hien Jain, Nityanand Reinis, Aigars |
author_facet | TV, Phu Tran, Thu Thao Hao, Huynh Trung Hau, Nguyen Thi Hien Jain, Nityanand Reinis, Aigars |
author_sort | TV, Phu |
collection | PubMed |
description | BACKGROUND: Postural Orthostatic Tachycardia Syndrome (POTS) is a common condition affecting more than 170 people per 100,000 population. However, POTS following COVID-19 vaccination remains a rare reporting in the medical literature. OBJECTIVE: We, herein, summarize and highlight the evidence that has been reported regarding POTS-like symptoms following COVID-19 vaccination. METHODS: We conducted a literature search and summarized the findings in the form of a narrative commentary. All types of publications (case reports/series, original articles, letters to editors, brief communications etc.) in English language were included. RESULTS: Whilst the exact pathogenetic mechanism behind POTS is yet to elucidated, there has been increasing evidence pointing towards an autoimmune dysfunction. Females were found to be predominantly affected (72%) with age range from 17 years to 52 years. Additionally, it seems that POTS-like symptoms could be triggered after immunization with Pfizer- BioNTech, Moderna, and Oxford-AstraZeneca COVID-19 vaccines. The symptoms typically appear within the first week, depending upon previous exposure to the virus and presence of other systemic conditions. In some patients, the condition is self-resolving. However, in others, non-pharmacological interventions coupled with negative ionotropic medications can be used for symptomatic management of the patients. CONCLUSIONS: Timely diagnosis and proper treatment are quintessential for ensuring early alleviation (and in some cases complete resolution) of symptoms. Furthermore, there may be episodes of relapse. Overall prognosis of the new-onset POTS-like symptoms is difficult to predict based on current literature. |
format | Online Article Text |
id | pubmed-10357168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103571682023-07-21 Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature TV, Phu Tran, Thu Thao Hao, Huynh Trung Hau, Nguyen Thi Hien Jain, Nityanand Reinis, Aigars Hum Antibodies Brief Report BACKGROUND: Postural Orthostatic Tachycardia Syndrome (POTS) is a common condition affecting more than 170 people per 100,000 population. However, POTS following COVID-19 vaccination remains a rare reporting in the medical literature. OBJECTIVE: We, herein, summarize and highlight the evidence that has been reported regarding POTS-like symptoms following COVID-19 vaccination. METHODS: We conducted a literature search and summarized the findings in the form of a narrative commentary. All types of publications (case reports/series, original articles, letters to editors, brief communications etc.) in English language were included. RESULTS: Whilst the exact pathogenetic mechanism behind POTS is yet to elucidated, there has been increasing evidence pointing towards an autoimmune dysfunction. Females were found to be predominantly affected (72%) with age range from 17 years to 52 years. Additionally, it seems that POTS-like symptoms could be triggered after immunization with Pfizer- BioNTech, Moderna, and Oxford-AstraZeneca COVID-19 vaccines. The symptoms typically appear within the first week, depending upon previous exposure to the virus and presence of other systemic conditions. In some patients, the condition is self-resolving. However, in others, non-pharmacological interventions coupled with negative ionotropic medications can be used for symptomatic management of the patients. CONCLUSIONS: Timely diagnosis and proper treatment are quintessential for ensuring early alleviation (and in some cases complete resolution) of symptoms. Furthermore, there may be episodes of relapse. Overall prognosis of the new-onset POTS-like symptoms is difficult to predict based on current literature. IOS Press 2023-07-13 /pmc/articles/PMC10357168/ /pubmed/37248893 http://dx.doi.org/10.3233/HAB-220013 Text en © 2023 – The authors. Published by IOS Press. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report TV, Phu Tran, Thu Thao Hao, Huynh Trung Hau, Nguyen Thi Hien Jain, Nityanand Reinis, Aigars Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature |
title | Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature |
title_full | Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature |
title_fullStr | Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature |
title_full_unstemmed | Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature |
title_short | Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature |
title_sort | postural orthostatic tachycardia syndrome-like symptoms following covid-19 vaccination: an overview of clinical literature |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357168/ https://www.ncbi.nlm.nih.gov/pubmed/37248893 http://dx.doi.org/10.3233/HAB-220013 |
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