Landscape of Double-Stranded DNA Breaks in Postmortem Brains from Alzheimer’s Disease and Non-Demented Individuals

BACKGROUND: Alzheimer’s disease (AD) brains accumulate DNA double-strand breaks (DSBs), which could contribute to neurodegeneration and dysfunction. The genomic distribution of AD brain DSBs is unclear. OBJECTIVE: To map genome-wide DSB distributions in AD and age-matched control brains. METHODS: We...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xiaoyu, Liu, Yan, Huang, Ming, Gunewardena, Sumedha, Haeri, Mohammad, Swerdlow, Russell H., Wang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357181/
https://www.ncbi.nlm.nih.gov/pubmed/37334609
http://dx.doi.org/10.3233/JAD-230316

Ejemplares similares

Ejemplares similares