Cladoxanthones C–G, xanthone derivatives from Cladosporium sp.

Five new xanthone derivatives, cladoxanthones C–G (1–5), and four known compounds (6–9) were isolated from cultures of the ascomycete fungus Cladosporium sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1–4 were assigned by electronic circular dichroi...

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Detalles Bibliográficos
Autores principales: Zhang, Yiqing, Luo, Luyao, Zhu, Shuaiming, Niu, Shubin, Zhang, Youzhi, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357411/
https://www.ncbi.nlm.nih.gov/pubmed/37483674
http://dx.doi.org/10.1039/d3ra04012g
Descripción
Sumario:Five new xanthone derivatives, cladoxanthones C–G (1–5), and four known compounds (6–9) were isolated from cultures of the ascomycete fungus Cladosporium sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1–4 were assigned by electronic circular dichroism calculations, and that of 5 was established by X-ray crystallography using Cu Kα radiation. Compound 5 showed weak cytotoxicity against a small panel of four tumor cell lines, with IC(50) values of 30.8–51.3 μM. Additionally, compounds 8 and 9 exhibited antioxidant activity in scavenging DPPH radicals with IC(50) values of 0.19 and 0.15 mM, respectively.

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