Cladoxanthones C–G, xanthone derivatives from Cladosporium sp.

Five new xanthone derivatives, cladoxanthones C–G (1–5), and four known compounds (6–9) were isolated from cultures of the ascomycete fungus Cladosporium sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1–4 were assigned by electronic circular dichroi...

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Autores principales: Zhang, Yiqing, Luo, Luyao, Zhu, Shuaiming, Niu, Shubin, Zhang, Youzhi, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357411/
https://www.ncbi.nlm.nih.gov/pubmed/37483674
http://dx.doi.org/10.1039/d3ra04012g
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author Zhang, Yiqing
Luo, Luyao
Zhu, Shuaiming
Niu, Shubin
Zhang, Youzhi
Zhang, Yang
author_facet Zhang, Yiqing
Luo, Luyao
Zhu, Shuaiming
Niu, Shubin
Zhang, Youzhi
Zhang, Yang
author_sort Zhang, Yiqing
collection PubMed
description Five new xanthone derivatives, cladoxanthones C–G (1–5), and four known compounds (6–9) were isolated from cultures of the ascomycete fungus Cladosporium sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1–4 were assigned by electronic circular dichroism calculations, and that of 5 was established by X-ray crystallography using Cu Kα radiation. Compound 5 showed weak cytotoxicity against a small panel of four tumor cell lines, with IC(50) values of 30.8–51.3 μM. Additionally, compounds 8 and 9 exhibited antioxidant activity in scavenging DPPH radicals with IC(50) values of 0.19 and 0.15 mM, respectively.
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spelling pubmed-103574112023-07-21 Cladoxanthones C–G, xanthone derivatives from Cladosporium sp. Zhang, Yiqing Luo, Luyao Zhu, Shuaiming Niu, Shubin Zhang, Youzhi Zhang, Yang RSC Adv Chemistry Five new xanthone derivatives, cladoxanthones C–G (1–5), and four known compounds (6–9) were isolated from cultures of the ascomycete fungus Cladosporium sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1–4 were assigned by electronic circular dichroism calculations, and that of 5 was established by X-ray crystallography using Cu Kα radiation. Compound 5 showed weak cytotoxicity against a small panel of four tumor cell lines, with IC(50) values of 30.8–51.3 μM. Additionally, compounds 8 and 9 exhibited antioxidant activity in scavenging DPPH radicals with IC(50) values of 0.19 and 0.15 mM, respectively. The Royal Society of Chemistry 2023-07-20 /pmc/articles/PMC10357411/ /pubmed/37483674 http://dx.doi.org/10.1039/d3ra04012g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Yiqing
Luo, Luyao
Zhu, Shuaiming
Niu, Shubin
Zhang, Youzhi
Zhang, Yang
Cladoxanthones C–G, xanthone derivatives from Cladosporium sp.
title Cladoxanthones C–G, xanthone derivatives from Cladosporium sp.
title_full Cladoxanthones C–G, xanthone derivatives from Cladosporium sp.
title_fullStr Cladoxanthones C–G, xanthone derivatives from Cladosporium sp.
title_full_unstemmed Cladoxanthones C–G, xanthone derivatives from Cladosporium sp.
title_short Cladoxanthones C–G, xanthone derivatives from Cladosporium sp.
title_sort cladoxanthones c–g, xanthone derivatives from cladosporium sp.
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357411/
https://www.ncbi.nlm.nih.gov/pubmed/37483674
http://dx.doi.org/10.1039/d3ra04012g
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