Design of Glycoengineered IL-4 Antagonists Employing Chemical and Biosynthetic Glycosylation

[Image: see text] Interleukin-4 (IL-4) plays a key role in atopic diseases. It coordinates T-helper cell differentiation to subtype 2, thereby directing defense toward humoral immunity. Together with Interleukin-13, IL-4 further induces immunoglobulin class switch to IgE. Antibodies of this type act...

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Autores principales: Thomas, Sarah, Fiebig, Juliane E., Kuhn, Eva-Maria, Mayer, Dominik S., Filbeck, Sebastian, Schmitz, Werner, Krischke, Markus, Gropp, Roswitha, Mueller, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357448/
https://www.ncbi.nlm.nih.gov/pubmed/37483220
http://dx.doi.org/10.1021/acsomega.3c00726

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