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Parkinson's disease‐linked V15A mutation facilitates α‐synuclein aggregation by reducing membrane affinity

Parkinson's disease can manifest either as a sporadic form, which is common, or as an inherited autosomal dominant trait resulting from missense mutations. Recently, the novel α‐synuclein variant V15A was identified in two Caucasian and two Japanese families with Parkinson's disease. Using...

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Detalles Bibliográficos
Autores principales: Buratti, Fiamma A., Fernández, Claudio Oscar, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357493/
https://www.ncbi.nlm.nih.gov/pubmed/37358478
http://dx.doi.org/10.1002/pro.4693