Development and Characterization of Pentaerythritol-EudragitRS100 Co-processed Excipients as Solid Dispersion Carriers for Enhanced Aqueous Solubility, In Vitro Dissolution, and Ex Vivo Permeation of Atorvastatin

[Image: see text] Atorvastatin (ATV), a lipid-lowering agent, has low oral bioavailability due to its poor water solubility, permeability, and low dissolution rate. Therefore, pentaerythritol-EudragitRS100 co-processed excipients (PECE) were synthesized, and their feasibility as solid dispersion car...

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Detalles Bibliográficos
Autores principales: Telange, Darshan R., Bhaktani, Neha M., Hemke, Atul T., Pethe, Anil M., Agrawal, Surendra S., Rarokar, Nilesh R., Jain, Shirish P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357539/
https://www.ncbi.nlm.nih.gov/pubmed/37483203
http://dx.doi.org/10.1021/acsomega.3c02280

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