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Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer’s Type

[Image: see text] Alzheimer’s disease (AD) is a progressive neurodegenerative disorder causing immense suffering for the patients. Dopamine D2 and 5-hydroxytryptamine receptor 1A (5-HT1A) receptors’ activation has been reported to play a crucial role in managing neurological outcomes in the brain an...

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Autores principales: Gupta, Tarun, Singh, Varinder, Hefnawy, Mohamed, Alanazi, Mohammed M., Alsuwayt, Bader, Kabra, Atul, Kumar, Amit, Pasricha, Chirag, Singh, Ravinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357558/
https://www.ncbi.nlm.nih.gov/pubmed/37483219
http://dx.doi.org/10.1021/acsomega.3c02550
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author Gupta, Tarun
Singh, Varinder
Hefnawy, Mohamed
Alanazi, Mohammed M.
Alsuwayt, Bader
Kabra, Atul
Kumar, Amit
Pasricha, Chirag
Singh, Ravinder
author_facet Gupta, Tarun
Singh, Varinder
Hefnawy, Mohamed
Alanazi, Mohammed M.
Alsuwayt, Bader
Kabra, Atul
Kumar, Amit
Pasricha, Chirag
Singh, Ravinder
author_sort Gupta, Tarun
collection PubMed
description [Image: see text] Alzheimer’s disease (AD) is a progressive neurodegenerative disorder causing immense suffering for the patients. Dopamine D2 and 5-hydroxytryptamine receptor 1A (5-HT1A) receptors’ activation has been reported to play a crucial role in managing neurological outcomes in the brain and other health disorders. This study aimed to investigate the role of aripiprazole, a dopamine D2 and 5-HT1A selective receptors’ activator, in the restoration of memory deficit induced by streptozotocin in mice. The cognitive functions of animals were determined using the Morris water maze. Brain sections were stained with hematoxylin and eosin and Congo red to examine the structural deviations. Brain oxidative stress (thiobarbituric acid reactive substance and glutathione), acetylcholinesterase activity, IL-6, and IL-10 were measured to assess biochemical alterations. Activation of D2 and 5-HT1A with aripiprazole attenuated STZ-induced cognitive deficit, increased brain GSH levels, reduced TBARS levels, AChE activity, IL-6 levels, and IL-10 levels and prevented STZ-induced brain anomalies in mice. Hence, the present study concluded that aripiprazole mitigated STZ-induced memory impairment and can be used as an efficacious therapeutic target for the management of AD.
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spelling pubmed-103575582023-07-21 Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer’s Type Gupta, Tarun Singh, Varinder Hefnawy, Mohamed Alanazi, Mohammed M. Alsuwayt, Bader Kabra, Atul Kumar, Amit Pasricha, Chirag Singh, Ravinder ACS Omega [Image: see text] Alzheimer’s disease (AD) is a progressive neurodegenerative disorder causing immense suffering for the patients. Dopamine D2 and 5-hydroxytryptamine receptor 1A (5-HT1A) receptors’ activation has been reported to play a crucial role in managing neurological outcomes in the brain and other health disorders. This study aimed to investigate the role of aripiprazole, a dopamine D2 and 5-HT1A selective receptors’ activator, in the restoration of memory deficit induced by streptozotocin in mice. The cognitive functions of animals were determined using the Morris water maze. Brain sections were stained with hematoxylin and eosin and Congo red to examine the structural deviations. Brain oxidative stress (thiobarbituric acid reactive substance and glutathione), acetylcholinesterase activity, IL-6, and IL-10 were measured to assess biochemical alterations. Activation of D2 and 5-HT1A with aripiprazole attenuated STZ-induced cognitive deficit, increased brain GSH levels, reduced TBARS levels, AChE activity, IL-6 levels, and IL-10 levels and prevented STZ-induced brain anomalies in mice. Hence, the present study concluded that aripiprazole mitigated STZ-induced memory impairment and can be used as an efficacious therapeutic target for the management of AD. American Chemical Society 2023-07-06 /pmc/articles/PMC10357558/ /pubmed/37483219 http://dx.doi.org/10.1021/acsomega.3c02550 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Gupta, Tarun
Singh, Varinder
Hefnawy, Mohamed
Alanazi, Mohammed M.
Alsuwayt, Bader
Kabra, Atul
Kumar, Amit
Pasricha, Chirag
Singh, Ravinder
Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer’s Type
title Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer’s Type
title_full Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer’s Type
title_fullStr Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer’s Type
title_full_unstemmed Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer’s Type
title_short Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer’s Type
title_sort ameliorating the role of aripiprazole in memory deficits induced by intracerebroventricular streptozotocin-induced dementia of alzheimer’s type
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357558/
https://www.ncbi.nlm.nih.gov/pubmed/37483219
http://dx.doi.org/10.1021/acsomega.3c02550
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