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Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin
[Image: see text] Among the novel drug delivery systems (DDSs), covalent organic frameworks (COFs) show promising features in pharmaceutical science. In this paper, an imine-linked COF with hexagonal topology was synthesized using the autoclave condition. Then, the prepared COF (APB-COF) was used as...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357574/ https://www.ncbi.nlm.nih.gov/pubmed/37483239 http://dx.doi.org/10.1021/acsomega.3c03316 |
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author | Mokhtari, Nazanin Dinari, Mohammad Khosravi Esmaeiltarkhani, Fatemeh |
author_facet | Mokhtari, Nazanin Dinari, Mohammad Khosravi Esmaeiltarkhani, Fatemeh |
author_sort | Mokhtari, Nazanin |
collection | PubMed |
description | [Image: see text] Among the novel drug delivery systems (DDSs), covalent organic frameworks (COFs) show promising features in pharmaceutical science. In this paper, an imine-linked COF with hexagonal topology was synthesized using the autoclave condition. Then, the prepared COF (APB-COF) was used as a pH-dependent carrier for in vitro release of doxorubicin (DOX). The intrinsic properties of APB-COF caused reaching an excellent drug encapsulation efficiency. DOX@APB-COF shows an exemplary pH-dependent release in two different pHs. DOX release at pH = 7.4 was 32%, which increased to 54% by changing the pH to the cancer cell pH (pH = 5.4). Moreover, the cytotoxicity of APB-COF and DOX@APB-COF was studied using the standard MTT test against MCF10 (normal breast cell line) and MDAmb231 cells (breast cancer cell line), respectively. It was observed that the APB-COF does not affect cell proliferation, whereas the DOX@APB-COF only limits cancer cell proliferation. Using APB-COF as the drug carrier can pave the way for using COFs in innovative DDSs. |
format | Online Article Text |
id | pubmed-10357574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-103575742023-07-21 Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin Mokhtari, Nazanin Dinari, Mohammad Khosravi Esmaeiltarkhani, Fatemeh ACS Omega [Image: see text] Among the novel drug delivery systems (DDSs), covalent organic frameworks (COFs) show promising features in pharmaceutical science. In this paper, an imine-linked COF with hexagonal topology was synthesized using the autoclave condition. Then, the prepared COF (APB-COF) was used as a pH-dependent carrier for in vitro release of doxorubicin (DOX). The intrinsic properties of APB-COF caused reaching an excellent drug encapsulation efficiency. DOX@APB-COF shows an exemplary pH-dependent release in two different pHs. DOX release at pH = 7.4 was 32%, which increased to 54% by changing the pH to the cancer cell pH (pH = 5.4). Moreover, the cytotoxicity of APB-COF and DOX@APB-COF was studied using the standard MTT test against MCF10 (normal breast cell line) and MDAmb231 cells (breast cancer cell line), respectively. It was observed that the APB-COF does not affect cell proliferation, whereas the DOX@APB-COF only limits cancer cell proliferation. Using APB-COF as the drug carrier can pave the way for using COFs in innovative DDSs. American Chemical Society 2023-07-03 /pmc/articles/PMC10357574/ /pubmed/37483239 http://dx.doi.org/10.1021/acsomega.3c03316 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Mokhtari, Nazanin Dinari, Mohammad Khosravi Esmaeiltarkhani, Fatemeh Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin |
title | Imine-Linked Covalent
Organic Frameworks: A Biocompatible
and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin |
title_full | Imine-Linked Covalent
Organic Frameworks: A Biocompatible
and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin |
title_fullStr | Imine-Linked Covalent
Organic Frameworks: A Biocompatible
and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin |
title_full_unstemmed | Imine-Linked Covalent
Organic Frameworks: A Biocompatible
and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin |
title_short | Imine-Linked Covalent
Organic Frameworks: A Biocompatible
and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin |
title_sort | imine-linked covalent
organic frameworks: a biocompatible
and ph-dependent carrier for in vitro sustained release of doxorubicin |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357574/ https://www.ncbi.nlm.nih.gov/pubmed/37483239 http://dx.doi.org/10.1021/acsomega.3c03316 |
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