Cargando…

Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin

[Image: see text] Among the novel drug delivery systems (DDSs), covalent organic frameworks (COFs) show promising features in pharmaceutical science. In this paper, an imine-linked COF with hexagonal topology was synthesized using the autoclave condition. Then, the prepared COF (APB-COF) was used as...

Descripción completa

Detalles Bibliográficos
Autores principales: Mokhtari, Nazanin, Dinari, Mohammad, Khosravi Esmaeiltarkhani, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357574/
https://www.ncbi.nlm.nih.gov/pubmed/37483239
http://dx.doi.org/10.1021/acsomega.3c03316
_version_ 1785075520430407680
author Mokhtari, Nazanin
Dinari, Mohammad
Khosravi Esmaeiltarkhani, Fatemeh
author_facet Mokhtari, Nazanin
Dinari, Mohammad
Khosravi Esmaeiltarkhani, Fatemeh
author_sort Mokhtari, Nazanin
collection PubMed
description [Image: see text] Among the novel drug delivery systems (DDSs), covalent organic frameworks (COFs) show promising features in pharmaceutical science. In this paper, an imine-linked COF with hexagonal topology was synthesized using the autoclave condition. Then, the prepared COF (APB-COF) was used as a pH-dependent carrier for in vitro release of doxorubicin (DOX). The intrinsic properties of APB-COF caused reaching an excellent drug encapsulation efficiency. DOX@APB-COF shows an exemplary pH-dependent release in two different pHs. DOX release at pH = 7.4 was 32%, which increased to 54% by changing the pH to the cancer cell pH (pH = 5.4). Moreover, the cytotoxicity of APB-COF and DOX@APB-COF was studied using the standard MTT test against MCF10 (normal breast cell line) and MDAmb231 cells (breast cancer cell line), respectively. It was observed that the APB-COF does not affect cell proliferation, whereas the DOX@APB-COF only limits cancer cell proliferation. Using APB-COF as the drug carrier can pave the way for using COFs in innovative DDSs.
format Online
Article
Text
id pubmed-10357574
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-103575742023-07-21 Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin Mokhtari, Nazanin Dinari, Mohammad Khosravi Esmaeiltarkhani, Fatemeh ACS Omega [Image: see text] Among the novel drug delivery systems (DDSs), covalent organic frameworks (COFs) show promising features in pharmaceutical science. In this paper, an imine-linked COF with hexagonal topology was synthesized using the autoclave condition. Then, the prepared COF (APB-COF) was used as a pH-dependent carrier for in vitro release of doxorubicin (DOX). The intrinsic properties of APB-COF caused reaching an excellent drug encapsulation efficiency. DOX@APB-COF shows an exemplary pH-dependent release in two different pHs. DOX release at pH = 7.4 was 32%, which increased to 54% by changing the pH to the cancer cell pH (pH = 5.4). Moreover, the cytotoxicity of APB-COF and DOX@APB-COF was studied using the standard MTT test against MCF10 (normal breast cell line) and MDAmb231 cells (breast cancer cell line), respectively. It was observed that the APB-COF does not affect cell proliferation, whereas the DOX@APB-COF only limits cancer cell proliferation. Using APB-COF as the drug carrier can pave the way for using COFs in innovative DDSs. American Chemical Society 2023-07-03 /pmc/articles/PMC10357574/ /pubmed/37483239 http://dx.doi.org/10.1021/acsomega.3c03316 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mokhtari, Nazanin
Dinari, Mohammad
Khosravi Esmaeiltarkhani, Fatemeh
Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin
title Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin
title_full Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin
title_fullStr Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin
title_full_unstemmed Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin
title_short Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent Carrier for In Vitro Sustained Release of Doxorubicin
title_sort imine-linked covalent organic frameworks: a biocompatible and ph-dependent carrier for in vitro sustained release of doxorubicin
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357574/
https://www.ncbi.nlm.nih.gov/pubmed/37483239
http://dx.doi.org/10.1021/acsomega.3c03316
work_keys_str_mv AT mokhtarinazanin iminelinkedcovalentorganicframeworksabiocompatibleandphdependentcarrierforinvitrosustainedreleaseofdoxorubicin
AT dinarimohammad iminelinkedcovalentorganicframeworksabiocompatibleandphdependentcarrierforinvitrosustainedreleaseofdoxorubicin
AT khosraviesmaeiltarkhanifatemeh iminelinkedcovalentorganicframeworksabiocompatibleandphdependentcarrierforinvitrosustainedreleaseofdoxorubicin