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Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study

BACKGROUND: To evaluate the effect of room air and sulfur hexafluoride (SF6) gas in idiopathic macular hole(MH)surgery. METHODS: Retrospective, interventional, and comparative study. 238 eyes with the idiopathic macular hole that underwent pars plana vitrectomy, internal limiting membrane peeling, f...

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Autores principales: Yao, Yuou, Yan, Huichao, Qu, Jinfeng, Dong, Chongya, Liang, Jianhong, Yin, Hong, Ren, Chi, Jin, Enzhong, Zhao, Mingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357688/
https://www.ncbi.nlm.nih.gov/pubmed/37474921
http://dx.doi.org/10.1186/s12886-023-03049-2
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author Yao, Yuou
Yan, Huichao
Qu, Jinfeng
Dong, Chongya
Liang, Jianhong
Yin, Hong
Ren, Chi
Jin, Enzhong
Zhao, Mingwei
author_facet Yao, Yuou
Yan, Huichao
Qu, Jinfeng
Dong, Chongya
Liang, Jianhong
Yin, Hong
Ren, Chi
Jin, Enzhong
Zhao, Mingwei
author_sort Yao, Yuou
collection PubMed
description BACKGROUND: To evaluate the effect of room air and sulfur hexafluoride (SF6) gas in idiopathic macular hole(MH)surgery. METHODS: Retrospective, interventional, and comparative study. 238 eyes with the idiopathic macular hole that underwent pars plana vitrectomy, internal limiting membrane peeling, fluid-air exchange, and 20% SF6 (SF6 group:125 eyes) or room air tamponade (air group: 113 eyes) were reviewed. The primary outcome measure was the closure rate of primary surgery. RESULTS: The baseline characteristics of the SF6 group and air group were comparable except for the hole size (479.90 ± 204.48 vs. 429.38 ± 174.63 μm, P = 0.043). The anatomical closure rate was 92.8% (116 / 125) with the SF6 group and 76.1% (86 / 113) with the air group (P < 0.001). A cut-off value of MH size to predict primary anatomical closure was 520 μm, which is based on the lower limit of 95% confidential interval of the MH size among the unclosed patients in the air group. There was no significant difference in anatomical closure rates between SF6 and air group (98.7% vs. 91.9%, P = 0.051) for MH ≤ 520 μm, whereas a significantly lower anatomical closure rate was shown in the air group than SF6 group (46.2% vs. 84.0%, P < 0.001) for MH > 520 μm. CONCLUSION: SF6 exhibited more effectiveness than air to achieve a good anatomical outcome for its longer tamponade when MH > 520 μm. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12886-023-03049-2.
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spelling pubmed-103576882023-07-21 Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study Yao, Yuou Yan, Huichao Qu, Jinfeng Dong, Chongya Liang, Jianhong Yin, Hong Ren, Chi Jin, Enzhong Zhao, Mingwei BMC Ophthalmol Research BACKGROUND: To evaluate the effect of room air and sulfur hexafluoride (SF6) gas in idiopathic macular hole(MH)surgery. METHODS: Retrospective, interventional, and comparative study. 238 eyes with the idiopathic macular hole that underwent pars plana vitrectomy, internal limiting membrane peeling, fluid-air exchange, and 20% SF6 (SF6 group:125 eyes) or room air tamponade (air group: 113 eyes) were reviewed. The primary outcome measure was the closure rate of primary surgery. RESULTS: The baseline characteristics of the SF6 group and air group were comparable except for the hole size (479.90 ± 204.48 vs. 429.38 ± 174.63 μm, P = 0.043). The anatomical closure rate was 92.8% (116 / 125) with the SF6 group and 76.1% (86 / 113) with the air group (P < 0.001). A cut-off value of MH size to predict primary anatomical closure was 520 μm, which is based on the lower limit of 95% confidential interval of the MH size among the unclosed patients in the air group. There was no significant difference in anatomical closure rates between SF6 and air group (98.7% vs. 91.9%, P = 0.051) for MH ≤ 520 μm, whereas a significantly lower anatomical closure rate was shown in the air group than SF6 group (46.2% vs. 84.0%, P < 0.001) for MH > 520 μm. CONCLUSION: SF6 exhibited more effectiveness than air to achieve a good anatomical outcome for its longer tamponade when MH > 520 μm. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12886-023-03049-2. BioMed Central 2023-07-20 /pmc/articles/PMC10357688/ /pubmed/37474921 http://dx.doi.org/10.1186/s12886-023-03049-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yao, Yuou
Yan, Huichao
Qu, Jinfeng
Dong, Chongya
Liang, Jianhong
Yin, Hong
Ren, Chi
Jin, Enzhong
Zhao, Mingwei
Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study
title Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study
title_full Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study
title_fullStr Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study
title_full_unstemmed Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study
title_short Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study
title_sort vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357688/
https://www.ncbi.nlm.nih.gov/pubmed/37474921
http://dx.doi.org/10.1186/s12886-023-03049-2
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