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Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative phosphorylation enhancement in cartilage promotes osteoarthritis progression

Osteoarthritis (OA) is a common disease characterized by cartilage degradation. Growing evidence showed that glucose metabolism impacts joint homeostasis and an imbalance between glycolysis and oxidative phosphorylation (OXPHOS) may exacerbate OA progression, however, a definitive link is yet to be...

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Detalles Bibliográficos
Autores principales:	Yang, Xian, Jiang, Qingsong, Luan, Tiankuo, Yu, Chao, Liu, Zhibo, Wang, Ting, Wan, Jingyuan, Huang, Jiayu, Li, Ke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357736/ https://www.ncbi.nlm.nih.gov/pubmed/37474941 http://dx.doi.org/10.1186/s12891-023-06585-6

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