Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription

Numerous mechanisms have shown that long noncoding RNAs (lncRNAs) promote the development of colorectal cancer (CRC), but the role of lnc-LRRTM4 in the progression of CRC remains unclear. In this article, we found that lnc-LRRTM4 was highly expressed in CRC tissues and cell lines and that lnc-LRRTM4...

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Autores principales: Zhang, Jingjie, Meng, Xianmei, Zhou, Yi, Jiang, Zhengyu, Chen, Hongsuo, Meng, Zhiyi, Zhang, Qi, Chen, Weichang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357798/
https://www.ncbi.nlm.nih.gov/pubmed/37468908
http://dx.doi.org/10.1186/s12935-023-02986-8
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author Zhang, Jingjie
Meng, Xianmei
Zhou, Yi
Jiang, Zhengyu
Chen, Hongsuo
Meng, Zhiyi
Zhang, Qi
Chen, Weichang
author_facet Zhang, Jingjie
Meng, Xianmei
Zhou, Yi
Jiang, Zhengyu
Chen, Hongsuo
Meng, Zhiyi
Zhang, Qi
Chen, Weichang
author_sort Zhang, Jingjie
collection PubMed
description Numerous mechanisms have shown that long noncoding RNAs (lncRNAs) promote the development of colorectal cancer (CRC), but the role of lnc-LRRTM4 in the progression of CRC remains unclear. In this article, we found that lnc-LRRTM4 was highly expressed in CRC tissues and cell lines and that lnc-LRRTM4 could promote the proliferation and metastasis of CRC cells. These consequences were achieved by lnc-LRRTM4 directly binding to the promoter of LRRTM4 to induce its transcription. Moreover, lnc-LRRTM4 enhanced the growth of CRC cells in vivo by promoting cell cycle progression and reducing apoptosis. Taken together, our results revealed that lnc-LRRTM4 promotes the proliferation and metastasis of CRC cells, suggesting that it may be a potential diagnostic and therapeutic target for CRC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-023-02986-8.
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spelling pubmed-103577982023-07-21 Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription Zhang, Jingjie Meng, Xianmei Zhou, Yi Jiang, Zhengyu Chen, Hongsuo Meng, Zhiyi Zhang, Qi Chen, Weichang Cancer Cell Int Research Numerous mechanisms have shown that long noncoding RNAs (lncRNAs) promote the development of colorectal cancer (CRC), but the role of lnc-LRRTM4 in the progression of CRC remains unclear. In this article, we found that lnc-LRRTM4 was highly expressed in CRC tissues and cell lines and that lnc-LRRTM4 could promote the proliferation and metastasis of CRC cells. These consequences were achieved by lnc-LRRTM4 directly binding to the promoter of LRRTM4 to induce its transcription. Moreover, lnc-LRRTM4 enhanced the growth of CRC cells in vivo by promoting cell cycle progression and reducing apoptosis. Taken together, our results revealed that lnc-LRRTM4 promotes the proliferation and metastasis of CRC cells, suggesting that it may be a potential diagnostic and therapeutic target for CRC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-023-02986-8. BioMed Central 2023-07-19 /pmc/articles/PMC10357798/ /pubmed/37468908 http://dx.doi.org/10.1186/s12935-023-02986-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhang, Jingjie
Meng, Xianmei
Zhou, Yi
Jiang, Zhengyu
Chen, Hongsuo
Meng, Zhiyi
Zhang, Qi
Chen, Weichang
Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription
title Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription
title_full Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription
title_fullStr Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription
title_full_unstemmed Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription
title_short Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription
title_sort lnc-lrrtm4 promotes proliferation, metastasis and emt of colorectal cancer through activating lrrtm4 transcription
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357798/
https://www.ncbi.nlm.nih.gov/pubmed/37468908
http://dx.doi.org/10.1186/s12935-023-02986-8
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