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Epidemiological, clinical, therapeutic features and predictors of death among COVID-19 patients hospitalized in Parakou: a cross-sectional study in Northern Benin

BACKGROUND: COVID-19 is an emerging contagious infection with polymorphic clinical manifestations. The purpose of this study was to describe the epidemiological, clinical, therapeutic features and identify the predictors of mortality among COVID-19 hospitalized cases in Parakou. METHODS: This was a...

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Autores principales: Angelo, Attinsounon Cossi, Clodel, Yamongbè, Léopold, Codjo, Serge, Adé, Ibrahim, Mama Cissé, Julien, Attinon, Roger, Klikpezo, de Tovè Kofi-Mensa, Savi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357870/
https://www.ncbi.nlm.nih.gov/pubmed/37474897
http://dx.doi.org/10.1186/s12879-023-08445-z
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author Angelo, Attinsounon Cossi
Clodel, Yamongbè
Léopold, Codjo
Serge, Adé
Ibrahim, Mama Cissé
Julien, Attinon
Roger, Klikpezo
de Tovè Kofi-Mensa, Savi
author_facet Angelo, Attinsounon Cossi
Clodel, Yamongbè
Léopold, Codjo
Serge, Adé
Ibrahim, Mama Cissé
Julien, Attinon
Roger, Klikpezo
de Tovè Kofi-Mensa, Savi
author_sort Angelo, Attinsounon Cossi
collection PubMed
description BACKGROUND: COVID-19 is an emerging contagious infection with polymorphic clinical manifestations. The purpose of this study was to describe the epidemiological, clinical, therapeutic features and identify the predictors of mortality among COVID-19 hospitalized cases in Parakou. METHODS: This was a cross-sectional, descriptive and analytic study. Systematic recruitment was used to include all patients hospitalized with COVID-19 from May 8, 2020, to December 31, 2021, whose medical records were available and usable. The variables studied were clinical and paraclinical signs, diagnostic and therapeutic means, evolution under treatment and prognostic factors. This study was approved by the Local Ethical Committee. The data were analyzed using Stata/MP 14.1 software. RESULTS: A total of 198 cases of COVID-19 were identified, 117 of whom were men. The mean age was 51.53 ± 19.51 years. The presenting signs were fever 146 (74.11%), cough 157 (79.70%) and dyspnea 118 (53.90%). It was severe COVID-19 in 108 cases (54.55%). Therapeutically, 95 patients (47.98%) had received the combination of Lopinavir/ritonavir and Ribavirin and 95 others (47.98%) received chloroquine. Recovery was noted in 151 (76.26%) patients. Mortality rate was 18.18%. Predictors of death were high blood pressure, presence of signs of severity, high-concentration mask ventilation used, and elevated transaminases. CONCLUSION: COVID-19 was a reality in Parakou, with a significant number of severe cases requiring hospitalization. Several factors are associated with the prognosis of the disease.
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spelling pubmed-103578702023-07-21 Epidemiological, clinical, therapeutic features and predictors of death among COVID-19 patients hospitalized in Parakou: a cross-sectional study in Northern Benin Angelo, Attinsounon Cossi Clodel, Yamongbè Léopold, Codjo Serge, Adé Ibrahim, Mama Cissé Julien, Attinon Roger, Klikpezo de Tovè Kofi-Mensa, Savi BMC Infect Dis Research BACKGROUND: COVID-19 is an emerging contagious infection with polymorphic clinical manifestations. The purpose of this study was to describe the epidemiological, clinical, therapeutic features and identify the predictors of mortality among COVID-19 hospitalized cases in Parakou. METHODS: This was a cross-sectional, descriptive and analytic study. Systematic recruitment was used to include all patients hospitalized with COVID-19 from May 8, 2020, to December 31, 2021, whose medical records were available and usable. The variables studied were clinical and paraclinical signs, diagnostic and therapeutic means, evolution under treatment and prognostic factors. This study was approved by the Local Ethical Committee. The data were analyzed using Stata/MP 14.1 software. RESULTS: A total of 198 cases of COVID-19 were identified, 117 of whom were men. The mean age was 51.53 ± 19.51 years. The presenting signs were fever 146 (74.11%), cough 157 (79.70%) and dyspnea 118 (53.90%). It was severe COVID-19 in 108 cases (54.55%). Therapeutically, 95 patients (47.98%) had received the combination of Lopinavir/ritonavir and Ribavirin and 95 others (47.98%) received chloroquine. Recovery was noted in 151 (76.26%) patients. Mortality rate was 18.18%. Predictors of death were high blood pressure, presence of signs of severity, high-concentration mask ventilation used, and elevated transaminases. CONCLUSION: COVID-19 was a reality in Parakou, with a significant number of severe cases requiring hospitalization. Several factors are associated with the prognosis of the disease. BioMed Central 2023-07-20 /pmc/articles/PMC10357870/ /pubmed/37474897 http://dx.doi.org/10.1186/s12879-023-08445-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Angelo, Attinsounon Cossi
Clodel, Yamongbè
Léopold, Codjo
Serge, Adé
Ibrahim, Mama Cissé
Julien, Attinon
Roger, Klikpezo
de Tovè Kofi-Mensa, Savi
Epidemiological, clinical, therapeutic features and predictors of death among COVID-19 patients hospitalized in Parakou: a cross-sectional study in Northern Benin
title Epidemiological, clinical, therapeutic features and predictors of death among COVID-19 patients hospitalized in Parakou: a cross-sectional study in Northern Benin
title_full Epidemiological, clinical, therapeutic features and predictors of death among COVID-19 patients hospitalized in Parakou: a cross-sectional study in Northern Benin
title_fullStr Epidemiological, clinical, therapeutic features and predictors of death among COVID-19 patients hospitalized in Parakou: a cross-sectional study in Northern Benin
title_full_unstemmed Epidemiological, clinical, therapeutic features and predictors of death among COVID-19 patients hospitalized in Parakou: a cross-sectional study in Northern Benin
title_short Epidemiological, clinical, therapeutic features and predictors of death among COVID-19 patients hospitalized in Parakou: a cross-sectional study in Northern Benin
title_sort epidemiological, clinical, therapeutic features and predictors of death among covid-19 patients hospitalized in parakou: a cross-sectional study in northern benin
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357870/
https://www.ncbi.nlm.nih.gov/pubmed/37474897
http://dx.doi.org/10.1186/s12879-023-08445-z
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