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Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces

Electrophysiological recording and stimulation are the gold standard for functional mapping during surgical and therapeutic interventions as well as capturing cellular activity in the intact human brain. A critical component probing human brain activity is the interface material at the electrode con...

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Autores principales: Vatsyayan, Ritwik, Lee, Jihwan, Bourhis, Andrew M., Tchoe, Youngbin, Cleary, Daniel R., Tonsfeldt, Karen J., Lee, Keundong, Montgomery-Walsh, Rhea, Paulk, Angelique C., U, Hoi Sang, Cash, Sydney S., Dayeh, Shadi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357958/
https://www.ncbi.nlm.nih.gov/pubmed/37476355
http://dx.doi.org/10.1557/s43577-023-00537-0
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author Vatsyayan, Ritwik
Lee, Jihwan
Bourhis, Andrew M.
Tchoe, Youngbin
Cleary, Daniel R.
Tonsfeldt, Karen J.
Lee, Keundong
Montgomery-Walsh, Rhea
Paulk, Angelique C.
U, Hoi Sang
Cash, Sydney S.
Dayeh, Shadi A.
author_facet Vatsyayan, Ritwik
Lee, Jihwan
Bourhis, Andrew M.
Tchoe, Youngbin
Cleary, Daniel R.
Tonsfeldt, Karen J.
Lee, Keundong
Montgomery-Walsh, Rhea
Paulk, Angelique C.
U, Hoi Sang
Cash, Sydney S.
Dayeh, Shadi A.
author_sort Vatsyayan, Ritwik
collection PubMed
description Electrophysiological recording and stimulation are the gold standard for functional mapping during surgical and therapeutic interventions as well as capturing cellular activity in the intact human brain. A critical component probing human brain activity is the interface material at the electrode contact that electrochemically transduces brain signals to and from free charge carriers in the measurement system. Here, we summarize state-of-the-art electrode array systems in the context of translation for use in recording and stimulating human brain activity. We leverage parametric studies with multiple electrode materials to shed light on the varied levels of suitability to enable high signal-to-noise electrophysiological recordings as well as safe electrophysiological stimulation delivery. We discuss the effects of electrode scaling for recording and stimulation in pursuit of high spatial resolution, channel count electrode interfaces, delineating the electrode–tissue circuit components that dictate the electrode performance. Finally, we summarize recent efforts in the connectorization and packaging for high channel count electrode arrays and provide a brief account of efforts toward wireless neuronal monitoring systems.
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spelling pubmed-103579582023-07-20 Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces Vatsyayan, Ritwik Lee, Jihwan Bourhis, Andrew M. Tchoe, Youngbin Cleary, Daniel R. Tonsfeldt, Karen J. Lee, Keundong Montgomery-Walsh, Rhea Paulk, Angelique C. U, Hoi Sang Cash, Sydney S. Dayeh, Shadi A. MRS Bull Article Electrophysiological recording and stimulation are the gold standard for functional mapping during surgical and therapeutic interventions as well as capturing cellular activity in the intact human brain. A critical component probing human brain activity is the interface material at the electrode contact that electrochemically transduces brain signals to and from free charge carriers in the measurement system. Here, we summarize state-of-the-art electrode array systems in the context of translation for use in recording and stimulating human brain activity. We leverage parametric studies with multiple electrode materials to shed light on the varied levels of suitability to enable high signal-to-noise electrophysiological recordings as well as safe electrophysiological stimulation delivery. We discuss the effects of electrode scaling for recording and stimulation in pursuit of high spatial resolution, channel count electrode interfaces, delineating the electrode–tissue circuit components that dictate the electrode performance. Finally, we summarize recent efforts in the connectorization and packaging for high channel count electrode arrays and provide a brief account of efforts toward wireless neuronal monitoring systems. 2023-05 2023-05-31 /pmc/articles/PMC10357958/ /pubmed/37476355 http://dx.doi.org/10.1557/s43577-023-00537-0 Text en https://creativecommons.org/licenses/by/4.0/Open access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Vatsyayan, Ritwik
Lee, Jihwan
Bourhis, Andrew M.
Tchoe, Youngbin
Cleary, Daniel R.
Tonsfeldt, Karen J.
Lee, Keundong
Montgomery-Walsh, Rhea
Paulk, Angelique C.
U, Hoi Sang
Cash, Sydney S.
Dayeh, Shadi A.
Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces
title Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces
title_full Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces
title_fullStr Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces
title_full_unstemmed Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces
title_short Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces
title_sort electrochemical and electrophysiological considerations for clinical high channel count neural interfaces
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357958/
https://www.ncbi.nlm.nih.gov/pubmed/37476355
http://dx.doi.org/10.1557/s43577-023-00537-0
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