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Adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: A report from the SURfit study

PURPOSE: Meeting intervention requirements is crucial in behavioral trials. We examined patterns and predictors of physical activity (PA) adherence and contamination in a 1‐year individualized randomized controlled PA behavioral intervention in childhood cancer survivors (CCS). METHODS: CCS aged ≥16...

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Autores principales: Jung, Ruedi, Zürcher, Simeon J., Schindera, Christina, Braun, Julia, Deng, Wei Hai, von der Weid, Nicolas X., Rueegg, Corina S., Kriemler, Susi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358195/
https://www.ncbi.nlm.nih.gov/pubmed/37199378
http://dx.doi.org/10.1002/cam4.6096
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author Jung, Ruedi
Zürcher, Simeon J.
Schindera, Christina
Braun, Julia
Deng, Wei Hai
von der Weid, Nicolas X.
Rueegg, Corina S.
Kriemler, Susi
author_facet Jung, Ruedi
Zürcher, Simeon J.
Schindera, Christina
Braun, Julia
Deng, Wei Hai
von der Weid, Nicolas X.
Rueegg, Corina S.
Kriemler, Susi
author_sort Jung, Ruedi
collection PubMed
description PURPOSE: Meeting intervention requirements is crucial in behavioral trials. We examined patterns and predictors of physical activity (PA) adherence and contamination in a 1‐year individualized randomized controlled PA behavioral intervention in childhood cancer survivors (CCS). METHODS: CCS aged ≥16 at enrolment, <16 at diagnosis, and ≥5 years in remission were identified from the Swiss Childhood Cancer Registry. We asked participants randomized to the intervention group to perform an additional ≥2.5 h of intense PA/week and controls to continue as usual. Adherence to the intervention was assessed by online diary (adherent if ≥2/3 of individual PA goal reached) and contamination for the control group by pre‐ and post‐questionnaire including PA levels (contaminated if >60 min increase/week in PA). Predictors of adherence/contamination including quality of life (36‐Item Short Form Survey) were assessed by questionnaire. We used logistic (control group) and mixed logistic regression models (exercise group) to estimate predictors of study adherence and contamination. RESULTS: One hundred and forty‐four survivors (30.4 ± 8.7 years old, 43% females) were included. Adherence was 48% (35/73) in the intervention group, while 17% (12/71) of controls contaminated group allocation. Predictors for PA adherence were female sex (OR 2.35, p = 0.03), higher physical (OR 1.34, p = 0.01) and mental quality of life (OR 1.37, p = 0.001), and week into the intervention (OR 0.98, p < 0.001). Clear differences in PA behavior of adherent and non‐adherent participants were seen from week four. No significant predictors for contamination were found for controls. CONCLUSION: Adherence to PA behavior interventions remain challenging in both groups. Further long‐term trials should consider intense motivational support within the first month, more detailed data collection for the control group, adjustments to power calculations and other study designs to minimize non‐adherence and contamination.
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spelling pubmed-103581952023-07-21 Adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: A report from the SURfit study Jung, Ruedi Zürcher, Simeon J. Schindera, Christina Braun, Julia Deng, Wei Hai von der Weid, Nicolas X. Rueegg, Corina S. Kriemler, Susi Cancer Med RESEARCH ARTICLES PURPOSE: Meeting intervention requirements is crucial in behavioral trials. We examined patterns and predictors of physical activity (PA) adherence and contamination in a 1‐year individualized randomized controlled PA behavioral intervention in childhood cancer survivors (CCS). METHODS: CCS aged ≥16 at enrolment, <16 at diagnosis, and ≥5 years in remission were identified from the Swiss Childhood Cancer Registry. We asked participants randomized to the intervention group to perform an additional ≥2.5 h of intense PA/week and controls to continue as usual. Adherence to the intervention was assessed by online diary (adherent if ≥2/3 of individual PA goal reached) and contamination for the control group by pre‐ and post‐questionnaire including PA levels (contaminated if >60 min increase/week in PA). Predictors of adherence/contamination including quality of life (36‐Item Short Form Survey) were assessed by questionnaire. We used logistic (control group) and mixed logistic regression models (exercise group) to estimate predictors of study adherence and contamination. RESULTS: One hundred and forty‐four survivors (30.4 ± 8.7 years old, 43% females) were included. Adherence was 48% (35/73) in the intervention group, while 17% (12/71) of controls contaminated group allocation. Predictors for PA adherence were female sex (OR 2.35, p = 0.03), higher physical (OR 1.34, p = 0.01) and mental quality of life (OR 1.37, p = 0.001), and week into the intervention (OR 0.98, p < 0.001). Clear differences in PA behavior of adherent and non‐adherent participants were seen from week four. No significant predictors for contamination were found for controls. CONCLUSION: Adherence to PA behavior interventions remain challenging in both groups. Further long‐term trials should consider intense motivational support within the first month, more detailed data collection for the control group, adjustments to power calculations and other study designs to minimize non‐adherence and contamination. John Wiley and Sons Inc. 2023-05-18 /pmc/articles/PMC10358195/ /pubmed/37199378 http://dx.doi.org/10.1002/cam4.6096 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Jung, Ruedi
Zürcher, Simeon J.
Schindera, Christina
Braun, Julia
Deng, Wei Hai
von der Weid, Nicolas X.
Rueegg, Corina S.
Kriemler, Susi
Adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: A report from the SURfit study
title Adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: A report from the SURfit study
title_full Adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: A report from the SURfit study
title_fullStr Adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: A report from the SURfit study
title_full_unstemmed Adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: A report from the SURfit study
title_short Adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: A report from the SURfit study
title_sort adherence and contamination in a 1‐year physical activity program in childhood cancer survivors: a report from the surfit study
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358195/
https://www.ncbi.nlm.nih.gov/pubmed/37199378
http://dx.doi.org/10.1002/cam4.6096
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