Synthesis and hypoglycemic activity of quinoxaline derivatives

In this study, a new series of quinoxalinone derivatives (5a–5p, 6a–6n) was designed and its hypoglycemic activity was evaluated. The results showed that compounds 5i and 6b exhibited stronger hypoglycemic effects than the lead compounds and were comparable to the positive control Pioglitazone. 5i a...

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Autores principales: Jia, Weidong, Wang, Jingjing, Wei, Chengxi, Bian, Ming, Bao, Shuyin, Yu, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358274/
https://www.ncbi.nlm.nih.gov/pubmed/37483267
http://dx.doi.org/10.3389/fchem.2023.1197124
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author Jia, Weidong
Wang, Jingjing
Wei, Chengxi
Bian, Ming
Bao, Shuyin
Yu, Lijun
author_facet Jia, Weidong
Wang, Jingjing
Wei, Chengxi
Bian, Ming
Bao, Shuyin
Yu, Lijun
author_sort Jia, Weidong
collection PubMed
description In this study, a new series of quinoxalinone derivatives (5a–5p, 6a–6n) was designed and its hypoglycemic activity was evaluated. The results showed that compounds 5i and 6b exhibited stronger hypoglycemic effects than the lead compounds and were comparable to the positive control Pioglitazone. 5i and 6b may exert hypoglycemic effects by alleviating cellular OS and modulating the interactions among GLUT4, SGLT2, and GLUT1 proteins. The alleviating cellular OS of compound 6b was better than that of 5i, and 6b was found to bind better than 5i for most of the screening targets. In summary, compound 6b is a potential lead compound with hypoglycaemic activity.3
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spelling pubmed-103582742023-07-21 Synthesis and hypoglycemic activity of quinoxaline derivatives Jia, Weidong Wang, Jingjing Wei, Chengxi Bian, Ming Bao, Shuyin Yu, Lijun Front Chem Chemistry In this study, a new series of quinoxalinone derivatives (5a–5p, 6a–6n) was designed and its hypoglycemic activity was evaluated. The results showed that compounds 5i and 6b exhibited stronger hypoglycemic effects than the lead compounds and were comparable to the positive control Pioglitazone. 5i and 6b may exert hypoglycemic effects by alleviating cellular OS and modulating the interactions among GLUT4, SGLT2, and GLUT1 proteins. The alleviating cellular OS of compound 6b was better than that of 5i, and 6b was found to bind better than 5i for most of the screening targets. In summary, compound 6b is a potential lead compound with hypoglycaemic activity.3 Frontiers Media S.A. 2023-07-06 /pmc/articles/PMC10358274/ /pubmed/37483267 http://dx.doi.org/10.3389/fchem.2023.1197124 Text en Copyright © 2023 Jia, Wang, Wei, Bian, Bao and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Jia, Weidong
Wang, Jingjing
Wei, Chengxi
Bian, Ming
Bao, Shuyin
Yu, Lijun
Synthesis and hypoglycemic activity of quinoxaline derivatives
title Synthesis and hypoglycemic activity of quinoxaline derivatives
title_full Synthesis and hypoglycemic activity of quinoxaline derivatives
title_fullStr Synthesis and hypoglycemic activity of quinoxaline derivatives
title_full_unstemmed Synthesis and hypoglycemic activity of quinoxaline derivatives
title_short Synthesis and hypoglycemic activity of quinoxaline derivatives
title_sort synthesis and hypoglycemic activity of quinoxaline derivatives
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358274/
https://www.ncbi.nlm.nih.gov/pubmed/37483267
http://dx.doi.org/10.3389/fchem.2023.1197124
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AT bianming synthesisandhypoglycemicactivityofquinoxalinederivatives
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